Misa Cal M software - Tutorial

Significance of the topic

Mobile spectroscopic analysis, particularly surface-enhanced Raman spectroscopy (SERS), provides rapid and in-field identification of molecular compounds across pharmaceutical, environmental, and security applications. The combination of portable Raman instrumentation and smart device apps enhances analytical flexibility, lowers deployment barriers, and accelerates data-driven decisions in quality control and research.

Objectives and overview of the tutorial

This tutorial introduces Misa Cal M, an Android mobile application designed to pair with the Metrohm Instant SERS Analyzer (Misa). It guides users through installation, connection, calibration, measurement, data management, and troubleshooting of the combined mobile-analyzer system. Readers will gain practical steps to deploy the solution in routine workflows.

Methodology and instrumentation

The mobile workflow relies on the following equipment and components:

• Metrohm Instant SERS Analyzer (Misa) equipped with Bluetooth® connectivity
• Misa Cal M Android app (version 1.1.0 or higher, Android 6.0+)
• Calibration Standard (ASTM 1840 reference) and Smart Tips (sample holders with interlock)
• Android smartphone or tablet (Bluetooth® and location services enabled)

The methodology covers:

• App installation from Google Play™ and granting required permissions
• Bluetooth pairing (PIN 9999) between Misa and the mobile device
• Daily calibration and system suitability tests using the Calibration Standard
• Sample acquisition under defined operating procedures
• Library and operating procedure management directly in the app

Main results and discussion

Misa Cal M provides an intuitive interface for:

• Instrument control: view status, initiate calibration, and run self-tests
• Acquisition management: customizable procedures for laser power, integration time, SERS matching, and multi-scan options
• Real-time identification: spectral matching against user and licensed libraries with configurable thresholds and result limits
• Sample data handling: metadata capture (geolocation, pictures), overlay and reprocess capabilities, and export of full or summary reports
• Library/operating procedure creation and import from external or email sources

This integrated approach ensures reproducible measurements, streamlined data archiving, and secure handling of licensed SERS libraries.

Benefits and practical applications

The Misa Cal M solution enables:

• On-site verification of chemical identities without laboratory infrastructure
• Rapid instrument qualification via automated calibration and suitability checks
• Centralized management of spectral libraries and procedures on mobile devices
• Enhanced data traceability through geotagging and photographic metadata

Use cases include field screening of contaminants, counterfeit drug detection, and process monitoring in remote locations.

Future trends and possibilities

Emerging trends may include cloud synchronization of spectral databases, AI-driven spectral interpretation, and cross-platform integration with quality-management systems. Expansion to iOS platforms and enhanced sharing capabilities through secure data repositories will further broaden applicability.

Conclusion

Misa Cal M represents a comprehensive mobile companion for the Metrohm Instant SERS Analyzer, offering end-to-end workflows from calibration to result reporting. The tutorial illustrates how to install, configure, and utilize the app for robust in-field Raman analysis, ultimately empowering users with rapid, reliable molecular identification.

References

• No external references were cited in this tutorial summary.