Metrohm Misa Raman - Product Manual

Significance of the Topic

The Metrohm Instant SERS Analyzer (Misa) enables rapid, on-site detection and identification of trace contaminants, illicit substances, and food additives using surface-enhanced Raman spectroscopy. Its portability, battery operation, and high spectral resolution support field and mobile-lab applications in forensic, food safety, and industrial quality control settings.

Objectives and Study Overview

This product manual aims to detail the design, safe handling, installation, operation, maintenance, and technical specifications of Misa. It guides users through system setup, software configuration, Smart Tip sampling methods, and performance verification procedures.

Methodology

Misa employs a 785 nm laser source coupled with Metrohm’s Orbital-Raster-Scan (ORS™) spectrograph to collect Raman spectra in the 400–2 300 cm⁻¹ range. Smart Tips integrate class 1 safety interlocks to ensure laser shutoff when opened or removed. Sampling formats include vial holders for liquid specimens and P-SERS strips for solid or swab samples. Data are acquired via Misa Cal desktop or Misa Cal M mobile applications over USB or Bluetooth.

Instrumentation

• Analyzer unit with built-in 785 nm, ≤100 mW laser
• Smart Tips: Vial Holder, P-SERS Attachment, Calibration Standard
• USB and Bluetooth® interfaces for power and data transfer
• Metrohm Misa Cal software (desktop) and Misa Cal M mobile app

Main Results and Discussion

Performance verification includes instrument calibration with an ASTM-standard reference, ensuring spectral resolution of 8–10 cm⁻¹. The interlocks and battery indicators enhance safety and usability. ORS technology provides spatial averaging to compensate for sample heterogeneity. Practical trials demonstrate reliable detection of trace analytes in variable field conditions.

Benefits and Practical Applications

• Portable, battery-powered operation for field deployment
• Rapid, non-destructive screening of liquids and surfaces
• High sensitivity to trace levels in forensics, environmental, and food analyses
• Flexible sampling with interchangeable Smart Tips

Future Trends and Applications

Advances may include integration with cloud-based spectral libraries, AI-driven identification algorithms, expanded Smart Tip chemistries, and miniaturized multi-laser modules for broader chemical coverage. Enhanced connectivity and real-time reporting will further streamline on-site decision-making.

Conclusion

Misa combines robust Raman spectroscopy with user-friendly design and safety features to address the growing need for portable, sensitive, and rapid analyte identification. Its modular Smart Tip system and versatile software support a wide range of applications in quality control, forensics, and environmental monitoring.

References

• Metrohm AG. Misa Product Manual, Firmware Version 10.0.1.0, 2020-06-26.