Mira P Handheld Raman Spectrometer

Significance of the Topic

On-site verification of materials is critical in industries such as pharmaceuticals, chemicals, and manufacturing. Handheld Raman spectroscopy enables rapid, non-destructive analysis at the point of need, reducing costly delays and ensuring product integrity.

Study Objectives and Overview

This application note introduces the Mira P handheld Raman spectrometer, designed for fast, reliable material identification and verification. It covers key features, operational workflow, regulatory compliance, and real-world performance metrics.

Methodology and Instrumentation

The Mira P employs orbital raster scan (ORS) technology to sample a larger area and improve reproducibility in heterogeneous formulations. Core components include:

• Mira P handheld Raman spectrometer with ORS optics
• Barcode scanner for automatic method selection and sample logging
• Smart sampling attachments: short-wave and long-wave dispersion probes for bag or bottle measurements
• Contact Ball Probe for liquids and powders
• Tablet Holder for solid dose forms
• Vial Holder for liquid or powder vials
• Calibration/Verification Accessory (CVA) with ASTM standard and NIST-traceable sample
• Integrated software supporting customizable operating procedures and reports

Main Results and Discussion

The Mira P delivers pass/fail verification, material identification via spectral library search, and multicomponent mixture matching in seconds. ORS scanning enhances detection of dispersed active pharmaceutical ingredients, minimizing false negatives. A guided workflow with barcode scanning and automatic reporting streamlines user interaction and ensures data integrity.

Practical Benefits and Applications of the Method

• Rapid throughput: analysis completed in seconds for QC and receiving inspections
• High confidence results: discriminatory algorithms and clear spectral match metrics
• Customizable models and reports: tailored to specific materials and regulatory requirements
• Single-handed operation: compact design and intuitive interface
• Compliance with FDA 21 CFR Part 11: audit trails, electronic records, and multilevel user access

Future Trends and Potential Applications

The next generation of handheld Raman systems will integrate cloud-based spectral libraries, AI-driven chemometrics, and enhanced connectivity for real-time data sharing. Advances in miniaturized optics and multiwavelength lasers may broaden applications to new material classes and field environments.

Conclusion

The Mira P handheld Raman spectrometer combines ORS technology, versatile sampling attachments, and regulatory compliance to deliver fast, reliable material verification at the point of need. It addresses the growing demand for on-site quality control in regulated industries.

Reference

No references were provided in the source document.