Applications from the field of Pharma & Biopharma | LabRulez ICPMS

LOCALIZING THE CONJUGATION SITES OF CYSTEINE-CONJUGATED ANTIBODY DRUG CONJUGATES BY IMPROVED LC-MS SUBUNIT ANALYSIS FOR ADC POSITIONAL ISOMER IDENTIFICATION

Posters

| 2015 | Waters

LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

Instrumentation

LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

Manufacturer

Waters

Industries

Pharma & Biopharma

Complete Characterization of a Cysteine- linked Antibody-Drug Conjugate Performed on a Hybrid Quadrupole-Orbitrap Mass Spectrometer with High Mass Range

Posters

| 2016 | Thermo Fisher Scientific (ASMS)

LC/HRMS, LC/MS/MS, LC/Orbitrap, LC/MS

Instrumentation

LC/HRMS, LC/MS/MS, LC/Orbitrap, LC/MS

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Characterization of C-terminal and Disulfide Bond Peptides of Monoclonal Antibody (mAb) on Q-TOF Mass Spectrometer

Applications

| 2019 | Shimadzu

LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

Instrumentation

LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

Manufacturer

Shimadzu

Industries

Pharma & Biopharma

Protein Clipping Variant Analysis of Vedolizumab using dedicated workflows in BioPharma Compass

Applications

| 2020 | Bruker

LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

Instrumentation

LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

Manufacturer

Bruker

Industries

Pharma & Biopharma

LCMS Bioanalysis of Antibody Drugs Using Fab-selective Proteolysis “nSMOL Method” — Selection of Signature Peptide —

Applications

| 2017 | Shimadzu

LC/MS, LC/MS/MS, LC/QQQ

Instrumentation

LC/MS, LC/MS/MS, LC/QQQ

Manufacturer

Shimadzu

Industries

Pharma & Biopharma

Monoclonal antibody characterization through native Orbitrap mass spectrometry leading to improved sensitivity and elucidation of microheterogeneity

Posters

| 2020 | Thermo Fisher Scientific (ASMS)

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma

Comparison of Sub-3-μm HP-SEC Columns for the Analysis of IgG Antibody Aggregates (HMWS) and Fragments (LMWS)

Applications

| 2020 | Waters

Consumables, LC columns, GPC/SEC

Instrumentation

Consumables, LC columns, GPC/SEC

Manufacturer

Waters

Industries

Pharma & Biopharma

Automated Protein Modification Characterization of the Intact and Subunit NIST Monoclonal Antibody Reference Standard with Waters UNIFI Scientific Information System

Applications

| 2017 | Waters

Ion Mobility, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

Instrumentation

Ion Mobility, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

Manufacturer

Waters

Industries

Pharma & Biopharma

High Throughput Peptide Mapping with the Vanquish UHPLC System and the Q Exactive HF Mass Spectrometer

Posters

| 2015 | Thermo Fisher Scientific

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Instrumentation

LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap

Manufacturer

Thermo Fisher Scientific

Industries

Pharma & Biopharma, Proteomics

Using Hydrophilic Interaction Chromatography for Heightened Product Characterization to Overcome Challenges with Hydrophobic Monoclonal Antibodies and Antibody Drug Conjugates

Applications

| 2016 | Waters

HPLC

Instrumentation

HPLC

Manufacturer

Waters

Industries

Pharma & Biopharma

Applications from the field of Pharma & Biopharma | LabRulez ICPMS

LOCALIZING THE CONJUGATION SITES OF CYSTEINE-CONJUGATED ANTIBODY DRUG CONJUGATES BY IMPROVED LC-MS SUBUNIT ANALYSIS FOR ADC POSITIONAL ISOMER IDENTIFICATION

Complete Characterization of a Cysteine- linked Antibody-Drug Conjugate Performed on a Hybrid Quadrupole-Orbitrap Mass Spectrometer with High Mass Range

Characterization of C-terminal and Disulfide Bond Peptides of Monoclonal Antibody (mAb) on Q-TOF Mass Spectrometer

Protein Clipping Variant Analysis of Vedolizumab using dedicated workflows in BioPharma Compass

LCMS Bioanalysis of Antibody Drugs Using Fab-selective Proteolysis “nSMOL Method” — Selection of Signature Peptide —

Monoclonal antibody characterization through native Orbitrap mass spectrometry leading to improved sensitivity and elucidation of microheterogeneity

Comparison of Sub-3-μm HP-SEC Columns for the Analysis of IgG Antibody Aggregates (HMWS) and Fragments (LMWS)

Automated Protein Modification Characterization of the Intact and Subunit NIST Monoclonal Antibody Reference Standard with Waters UNIFI Scientific Information System

High Throughput Peptide Mapping with the Vanquish UHPLC System and the Q Exactive HF Mass Spectrometer

Using Hydrophilic Interaction Chromatography for Heightened Product Characterization to Overcome Challenges with Hydrophobic Monoclonal Antibodies and Antibody Drug Conjugates

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