News from LabRulezICPMS Library - Week 46, 2024
- Photo: LabRulezICPMS Library
Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in week 46, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!
👉 SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT ICPMS AND RELATED TECHNIQUES
👉 Need info about different analytical techniques? Peek into LabRulezLCMS or LabRulezGCMS libraries.
This week we bring you applications and other documents by Agilent Technologies, Shimadzu, Anton Paar, and Thermo Fisher Scientific!
1. Agilent Technologies: Support for 21 CFR Part 11 and Annex 11 Compliance: ICP-MS MassHunter Workstation Plus Software
- Technical note
Overview
OpenLab Server and ECM XT are ideal compliance solutions for medium to large-sized and expanding laboratories with multiple ICP-MS instruments, while OpenLab ECM is suitable for large laboratories wishing to manage electronic records from multiple instruments and sites. However, the cost and complexity of these server-based compliance solutions may not be appropriate for smaller laboratories that require a simple set of compliance tools to manage records from a single ICP-MS instrument.
For these smaller laboratories, the Agilent ICP-MS MassHunter Workstation Plus software provides a lower-cost route to complying with 21 CFR Part 11 and Annex 11. Workstation Plus is installed on the ICP-MS instrument PC to provide a simple and cost-effective compliance solution for a single Agilent ICP-MS or ICP-QQQ instrument.
In common with OpenLab Server, ECM XT, and ECM integration, the ICP-MS MassHunter User Access Control option uses OpenLab Shared Services (OLSS) functions to control user access to the workstation and record application and workstation audit trails.
Compliance components
Compliance with regulations is a key aspect of an analytical laboratory’s operation in many industries, such as pharmaceutical manufacturing, where the principles of good manufacturing practice (GMP) apply.
The four components of compliance related to analytical instruments are:
- Design qualification (DQ), manufacturing quality control, lifecycle management and documentation, and installation and operational qualification (IQ/OQ), for analytical instruments and their software.
- Control of user access to the workstation for instrument control and data processing (restricted user login access with password protection).
- Electronic records security, integrity and traceability (secure storage, file versioning, audit trail, electronic signatures, and archive/retrieval).
- Control of system operation, performance verification (PQ), physical access to the laboratory and associated equipment, Standard Operating Procedures, training and records.
2. Thermo Fisher Scientific: Profiling the elemental composition of whisky using inductively coupled plasma mass spectrometry (ICP-MS)
- Application
Goal
This application note will highlight how whisky samples can be comprehensively analyzed for their elemental composition and how this can help to unravel differences according to their geological origin as well as in the processing.
Introduction
The fermentation of foods and grains has a long history in human civilizations. Fermentation (and subsequent production of alcoholic beverages) has helped to make foods and drinks more durable, for example as an alternative to quickly degrading drinking water supplies on sea travel.
Whisky refers to a liquor made from fermented grain mash, often barley, corn, rye, and wheat. The main whisky producing countries are Scotland, Ireland, and the US, and controls over geographic origin are in place to maintain overall brand integrity.
Due to the large profit range especially for aged and rare whisky from specific manufacturers or regions, adulteration or incorrect labeling causes issues. There are a series of marker compounds that can be analyzed using gas chromatography-mass spectrometry to identify whisky adulteration,1 but the elemental composition can also provide relevant insights. There are certain elements that are known to vary in soils and may be used as indicators for geographical origin or to characterize relevant and unique steps in manufacturing. However, due to the distillation process, they may be depleted significantly in the final spirit compared to the original grain. This means highly sensitive instrumentation is needed to detect potentially small differences in concentrations.
Due to the alcohol content of around 40%, direct analysis using ICP-MS is often not possible. However, a reduction of the alcohol content by dilution makes the analysis possible without major changes to the sample introduction system (i.e., addition of oxygen to the plasma). Spectral and physical interferences however need to be considered. First, the remaining alcohol content changes the viscosity of the sample solutions and will therefore affect flow rates and nebulization efficiency in the sample introduction system. This can be addressed by preparation of matrix-matched calibration standards. Another reason to use matrix-matched calibration standards is the fact that analytes like arsenic and selenium are prone to signal enhancement in the presence of carbon and may therefore lead to false positive results if this is not compensated for. Last but not least, carbon can contribute to the formation of polyatomic interferences, such as 40Ar12C+ on 52Cr.
Conclusion
This study demonstrates that whisky, as well as other alcoholic beverages, can be analyzed for its complete trace elemental profile using the iCAP MSX ICP-MS following a simple dilution. The high robustness of the plasma as well as the re-designed sample introduction system allows solutions containing approximately 10 vol% of EtOH to be aspirated. Only minor changes to the sample introduction configuration were made to maximize sensitivity and account for the expected lower nebulizer flow rate. The data specifically demonstrates the high sensitivity of the instrument and its ability to remove polyatomic interferences. This in turn can be used to detect a wide range of elements that may show variability in whisky (and potentially other spirits derived from fermented agricultural products) based on geological conditions and/or processing materials or equipment used.
3. Shimadzu: Analysis of Black Mass Using ICPE-9800 for Enhancing Accuracy of EDX-7200 Results
- Application
User Benefits
- CPE-9800 Series allows in-depth analysis of black mass samples for calibration of EDX-7200 and investigation of out-of-the-ordinary samples identified in process-control.
- EDX-7200 Series represents a very fast tool for on-site process control with little sample preparation.
- Both instruments complement another and provide any user with a full set of capabilities for their endeavors.
Introduction
In the recycling process of lithium-ion batteries (LIB) black mass is an intermediate product from which, through various processes, precious metals like nickel, manganese and cobalt may be extracted. Any company trying to economically recover these valuable components requires information on the
elemental composition of the black mass to be used as the input material to their processes. At the same time, the producers of black mass strive to control their mechanical stage of the recycling process to assure a constant quality of their product. Both parties require instrumentation allowing fast and accurate elemental analysis for quality control.
Strengths and weaknesses of ED-XRF and ICP-OES
A great strength of EDX-7200 is the capability to directly analyze solid samples with little sample preparation. However, it may be difficult to spot interferences and gauge the accuracy of the obtained result. Sample preparation for analysis using ICPE-9820 can be time-consuming and complex, but the obtainable results may be more easily evaluated to spot possible biases due to matrix effects. Preparing calibration standards based on certified reference materials (CRMs) traceable to SI units is easy for liquid samples. This makes ICPE-9820 suitable to be used for preparing reference values on production samples. The complementary strengths and weaknesses of both techniques make Shimadzu’s EDX-7200 Series and ICPE-9800 Series a conclusive solution for the elemental analysis of black mass.
This application shows how to analyze black mass using ICPE-9800 to obtain an accurate reference value for EDX analysis1).
Conclusion
Shimadzu’s ICPE-9800 Series allows to conveniently validate obtained measurement results due to the ability to compare and add additional analysis lines after measurement. Liquid solutions allow for dilution or spike recovery experiments, that cannot be easily recreated with solid samples. Compared to ED-XRF however, sample preparation is vastly more extensive. That is why both techniques complement another that well. The herewith presented results will serve as reference values for calibration of Shimadzu’s EDX-7200 to set up as a fast analysis procedure for on-site analysis of black mass that is equivalent to results obtained using ICPE-9800 Series2).
4. Anton Paar: Solutions for Lead-Acid Batteries, Lithium-Ion Batteries, and Fuel Cells
- Brochure
Measuring Instruments for Optimized Battery and Fuel Cell Production
Successful manufacturing and performance of batteries and fuel cells rely on a suitable combination of functional materials with the right physicochemical properties.
Anton Paar has the tools to help you characterize, monitor, and investigate your battery’s or fuel cell’s key components. With the broadest portfolio of measuring instruments, we have a solution for your challenges in the research, production, and maintenance of lead-acid batteries, lithium-ion batteries and fuel cells.
SOLUTIONS FOR LEAD-ACID BATTERIES
Whether you are producing, maintaining, or servicing lead-acid batteries, you want to know the concentration of sulfuric acid in the battery and therefore the state of charge. To determine the concentration, use a digital density meter or digital hydrometer, either in your laboratory or out in the field.
- LEAD-ACID BATTERY MANUFACTURING
- LEAD-ACID BATTERY MAINTENANCE AND SERVICE
SOLUTIONS FOR LITHIUM-ION BATTERIES
Anton Paar delivers solutions for the quality control of raw materials, electrolytes, and solvents, and helps you characterize active materials for research
and product development.
- DENSITY, REFRACTIVE INDEX, AND CONCENTRATION MEASUREMENT
- PARTICLE CHARACTERIZATION
- SURFACE AND PORE SIZE ANALYSIS
- SURFACE CHARACTERIZATION
- VISCOSITY MEASUREMENTS AND RHEOLOGICAL INVESTIGATIONS
- MICROWAVE DIGESTION AND MICROWAVE SYNTHESIS
- SMALL-ANGLE X-RAY SCATTERING
- RAMAN SPECTROSCOPY
- FLASH POINT TESTING
SOLUTIONS FOR FUEL CELLS
Fuel cell development and production involves nanoscale engineering, optimizing and controlling both the particle size of the catalyst and the fluid transport properties of gases and vapors. Particle size analysis on the micrometer scale also plays a major part in the effective fabrication of electrode materials.
- Gas diffusion layer
- Catalyst
- Catalyst support
- Electrodes
- Proton exchange membrane
