News from LabRulezICPMS Library - Week 45, 2024

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in week 45, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!

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This week we bring you applications, posters, and other documents by Agilent Technologies, Shimadzu, Anton Paar, and Thermo Fisher Scientific!

1. Thermo Fisher Scientific / WPC: Hyphenation of a high-speed laser ablation system to Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for imaging applications

• Poster (WPC)

ABSTRACT

Purpose: Demonstrate the capabilities and limitations of the combination of a new laser-ablation systems dedicated to high-speed mapping with quadrupole based ICP-MS systems.

Methods: An Elemental Scientific Lasers imageGEO193 Laser Ablation system fitted with a TwoVol3 Ablation chamber was directly coupled with a Thermo Scientific™ iCAP™ TQ ICP-MS using a compatible Dual Concentric Injector. Data was acquired using Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution™ (ISDS) Software and processed using Iolite™ Laser Ablation Data Reduction Software.

Results: A series of tooth samples containing a range of elements in localized phases was analyzed to demonstrate the ease of coupling to a commercially available high-speed mapping laser ablation system, ease of dwell-time optimization for best signal-to-background ratio and image contrast across all scanned elements, and finally fast analysis times from sampling to image.

CONCLUSIONS

Through careful optimization of laser ablation and ICP-MS parameters, it is possible to generate high quality multi-elemental images at a fast rate. The use of new low-dispersion laser ablation cells and aerosol transfer technology is not limited to simultaneous mass spectrometers and is also applicable to sequential scanning mass spectrometers such as Quadrupole ICP-MS.

The major limitation of coupling low-dispersion Laser Ablation systems to sequential mass spectrometers is the limited number of elements that can be scanned; however, this is offset by the sensitivity and the specificity of, especially, triple quadrupole ICP-MS systems for the reduction of interferences on select analytes.

Most imaging experiments can be reduced to three or four analytes of interest, and in these cases LA-ICP-MS coupled to Triple Quadrupole ICP-MS using a low-dispersion, fast imaging setup can provide the analytical data quality required to answer challenging research questions.

2. Shimadzu: Study on the Mechanism of Early Delivery by Multi-Omics Analysis of Metabolites, Elements and Bacterial Flora in Amniotic Fluid

• Application

Abstract

A gas chromatograph mass spectrometer (GCMS-TQ™8040 NX) and an energy-dispersive X-ray fluorescence spectrometer (EDX-7200) were used to analyze metabolites (488 components) and elements (78 elements) contained in the amniotic fluid of pregnant women. These data were combined with amniotic fluid microbiota (approximately 250 species of microorganisms) measured using a miniature next-generation sequencer
(MinION Mk1C System, Oxford Nanopore Technologies, Inc.) and 16 items of labor data (e.g., neonatal weight) to analyze differences between preterm and normal births. Volcano plot and metabolic pathway analyses were performed using Multi-omics Analysis Package based on the 740 items detected. In this application, we introduce an example of multi-omics analysis conducted by gender and time series.

Introduction

Preterm delivery refers to delivery at a gestational age of 22 weeks or less than 37 weeks, which can have a significant impact on the health and development of the newborn and the life of the family. This problem occurs worldwide: in 2020, 1/10 of all births were preterm¹⁾ (Fig. 1). Prematurity is the leading cause of early childhood mortality, so there is an urgent need to promote research on preterm birth.

However, the global rate of premature birth reduction from 2010 to 2020 was only 0.14 %, indicating that the birth cycle has not improved. It is known that preterm birth is closely related to amniotic fluid, and it is used as a research object in preterm birth²⁾. Amniotic fluid is approximately 500 mL of water, contains fetal urine, sloughed cells, inflammatory substances, etc., and is a valuable source of information for understanding
fetal growth and health³⁾. Measuring metabolites in amniotic fluid helps assess the fetus's metabolic activity and nutritional status. Elemental measurements can also determine the extent of fetal development and environmental exposure. It is also essential to measure the bacterial flora in the amniotic fluid. It has been found that about 80 % of preterm births occur in pregnant women who have a chain of bacterial infections from the vagina to the uterus and from the uterus to the amniotic fluid ⁴⁾.

In this study, we used a gas chromatograph mass spectrometer GCMS-TQ8040 NX, an energy-dispersive X-ray fluorescence spectrometer EDX-7200, and a miniature next-generation sequencer MinION Mk1C to measure primary metabolites, elements, and flora in the amniotic fluid of preterm and term pregnant women (Fig. 2). These data were combined with 16 birth delivery data items (e.g., female age, newborn weight, etc.),
and the differences in amniotic fluid content between preterm and term births were visualized using Multi-omics Analysis Package.

Conclusion

Amniotic fluid from 6 pregnant women (3 preterm births and 3 term births) was measured using a next-generation sequencer (MinION Systems, Oxford Nanopore Technologies, Inc.), a gas chromatography-mass spectrometer (GCMS-TQ8040 NX), and an energy-dispersive X-ray fluorescence spectrometer (EDX-7200) to evaluate the intestinal microbiota (approximately 250 species of microorganisms), metabolites (approximately 500 components), and elements (approximately 80 elements). Metabolic pathway analysis was performed using Multi-omics Analysis Package based on approximately 700 items detected.

In metabolic pathway analysis, not only the accumulated amount of metabolites, but also the ratio of product/substrate or its reciprocal substrate/product was automatically created in Multi-omics Analysis Package and used as a new variable to be read into class cluster analysis, etc., thereby enabling statistical analysis from a perspective different from the accumulated amount.

3. Agilent Technologies: Improving Spectral Quality Using Beam Collimation Control

• Technical note

Benefits of the Agilent Cary 7000 Universal Measurement Spectrophotometer with high f-number apertures for superior data quality and accuracy

Introduction

In spectroscopy, the quality of spectral data depends greatly on the incident beam that passes through the sample being analyzed. For samples analyzed at large angles of incidence (AOI), such as bandpass and edge filters (e.g., beam splitters), maintaining a high degree of beam collimation is necessary to achieve optimal results. This control is achieved by adjusting the incident beam using apertures within the spectrophotometer that can be customized to meet the specific requirements of the application.

In this work, an Agilent Cary 7000 UV-Vis-NIR spectrophotometer that includes the Agilent Cary Universal Measurement Accessory (UMA) was used. The degree of beam collimation was investigated using different apertures within the UMA to enhance data quality for the determination of the edge steepness of an optical filter.

Conclusion

Characterizing the edge steepness of optical filters is an important measurement for manufacturers and users of these types of devices. The steeper the edge, the better the quality of the filter, so careful determination of edge steepness is required to differentiate between high and low quality filters. Accurate measurements depend on the half cone angle of the apertures used in spectrophotometers to control the degree of collimation.

This study has shown that the degree of collimation on the Agilent Cary 7000 Universal Measurement Spectrophotometer (UMS) that includes the Agilent Cary Universal Measurement Accessory (UMA) can be controlled precisely using different horizontal apertures ranging from 0.25 to 3°.

Exploring the use of higher f-number optics in the incident beam of the UMA can lead to improved sensitivity and accuracy in various spectroscopic applications. This performance was demonstrated by the investigation of the edge steepness of a beam splitter. The best data were acquired by the Cary UMA with collimation control using a 0.25° (f/35) horizontal aperture.

The UMA with optimized and controlled beam collimation enables the complete characterization of optical samples, ensuring optimal performance of final components.

4. Anton Paar: Beer Analysis Overview

• Brochures and Specifications

The Market Leader in Beer Analysis

Over the 50 years we’ve spent as market leader in offering analytical solutions for the beverage industry, we’ve developed a range of technical innovations that increase the accuracy and speed of your measurements.

We’re always a step ahead of fast-evolving beverage industry trends and applications, providing solutions that position you one step ahead, too. Whether you’re analyzing a malty pale ale or a crisp lager, we’ll help you save time, analyze with ease, and deliver a premium product.

Our Product Portfolio for Beer Analysis

DMA 35: Portable density meter

• Perform fast, reliable fermentation monitoring from -10 °Plato to +85 °Plato
• Fill samples at temperatures up to 100 °C (hot wort)
• Get quick results with just 2 mL sample volume
• Store up to 30 measuring methods and up to 250 sample IDs

Alex 500: Alcohol and extract meter

• Monitor up to 40 fermentation processes simultaneously
• Enjoy patented density and NIR technology in a single instrument
• Get direct, real-time results 
• Rely on semi-automated sampling and a standardized sample handling SOP

Alcolyzer M Beer: Beer analyzing system

• Perform selective alcohol analysis
• Get results in less than three minutes
• Calibrate the instrument easily and perform product-independent adjustments

PO 5000: Total package oxygen meter

• Measure total package oxygen directly out of cans, glass bottles, and PET bottles
• Get results in less than four minutes
• Enjoy self-cleaning and minimum maintenance

DMA 4101, DMA 4501, DMA 5001: The fastest, most-accurate density meters

• Analyze beer and get results with 4-digit accuracy in 20 seconds (up to 6-digit density accuracy available)
• Track and eliminate variations in your production and achieve consistency in every batch
• Enjoy higher throughput with automated filling, measuring, and cleaning options
• Rely on technology that’s been in the field for over 40 years

Complete Your Beer Analysis

We’re the world’s first full-range supplier for beer analysis. With 25 laboratory and process instruments, you can trace 15+ parameters from any location in the plant. Streamlining your beer’s quality has never been so easy.