20th Blue Danube Symposium on Heterocycles in Chemistry

The the date of the conference is approaching!

The jubilant 20th Blue Danube Symposium on Heterocycles in Chemistry will be held on 25 – 28 August 2024 in Prague, Czech Republic.

Previously known as the Blue Danube Symposium on Heterocyclic Chemistry, this esteemed event has a rich history dating back to the year 1991. Over the past three decades, this symposium has been organized in various cities in Austria, Czech Republic, Hungary, Slovakia, and Slovenia, yet Prague has not had the honor of hosting this remarkable conference—until now. It is with great pride that we announce the hosting of the jubilant 20th edition of the conference here in Prague.

👉 Conference profile on LabRulez portals

One might be wondering, why to change the name after 33 years? The answer is simple: as chemistry evolves, so must our approach. The name change is not merely symbolic; it signifies our commitment to evolving the conference concept to better serve the scientific community. We aim to broaden the conference’s appeal, welcoming scientists from diverse fields—medicinal chemistry, biological chemistry, material chemistry, organometallic chemistry, and beyond—whose chemistry might not be fully focused on heterocyclic chemistry, but the pivotal role of heterocycles in their work is recognized.

Prague, with its rich history and vibrant scientific community, serves as the perfect place to kick off this transformative change. We extend a warm invitation to join us in August in Prague!

Dr. Lukáš Rýček, M.Sc. (Charles University, Department of Organic Chemistry; Faculty of Science)

ONLINE REGISTRATION AND ABSTRACT FORM

Programme

Framework Programme

20th Blue Danube Symposium on Heterocycles in Chemistry - Framework Programme.

Detailed Programme

Sunday, August 25, 2024

14:00 – 14:30 | Opening ceremony

14:30 – 15:30 | Plenary Lecture

• Lutz Ackermann (Georg-August-University Göttingen) - Electrocatalyzed C-H Activation with Potential

15:30 – 16:15 | Coffee break

Chair: Miroslav Soural

16:15 – 16:45 | Blue Danube Senior

• Martin Putala - Design of Oligothienyl Acenes with Electron Withdrawing Groups as n-type Semiconductors

16:45 – 17:00 | Oral communication 1

• Aleš Růžička – The Lightest Metal in Action; Novel Heterocycles, Associates and Clusters of Organolithiums

17:00 – 17:15 | Oral communication 2

• Sergio Armantia Matheu – Development of Novel Fluorescent Dyes and Their Application as Probes to Study Biological Processes

17:15 – 17:30 | Oral communication 3

• Petra Sőregi – High density information storage through isotope ratio encoding

17:30 – 17:45 | Oral communication 4

• Kiryl Vasiutovich – The use of palladium-catalyzed tandem reactions in the synthesis of poly(hetero)cyclic and spirocyclic compounds

17:45 – 18:00 | Oral communication 5

• Stanislav Kukla – Merck Lecture – Synple, Safe and Sustainable SnAP Synthesis of Saturated N-Heterocycles

18:00 – 20:00 | Welcome reception

Monday, August 26, 2024

Chair: Martin Putala

9:00 – 9:45 | Invited Lecture

• Michal Hocek (Institute of Organic Chemistry and Biochemistry of The CAS) - Modifications of Heterocyclic Nucleobases in Nucleotides and Nucleic Acids for Applications in Chemical Biology

9:45 – 10:05 | Blue Danube Junior

• Bartholomäus Pieber (Institute of Science and Technology Austria – ISTA) - Light-Mediated Nickel Catalysis Enabled by Donor-Acceptor Ligands

10:05 – 10:20 | Oral communication 6

• Ines Kulašić – Visible-light-induced transformations of pyrazolo[1,2-a]pyrazolones

10:20 – 10:35 | Oral communication 7

• Ivana Weisheitelová – 5-Aryldeazaalloxazine radicals as a new efficient tool in photoreductions

10:35 – 11:00 | Coffee break

Chair: Marko D. Mihovilovic

11:00 – 11:30 | Blue Danube Senior

• Péter Kele (Research Centre for Natural Sciences, Hungary) - Bioorthogonal Modulation of Photoresponsivity and Vice Versa

Péter Kele (Research Centre for Natural Sciences, Hungary)

11:30 – 11:45 | Oral communication 8

• Jure Gregorc – Trifluoromethylthiolation of aromatic amino acids: Peptide late-stage functionalization, local hydrophobicity modulation and selective post-oxidation

11:45 – 12:00 | Oral communication 9

• Grisa Princic – Advanced Reagent for Nucleophilic Fluorination

12:00 – 12:15 | Oral communication 10

• Antonio Massa – Organocascade reactions of functionalized α-amidosulfones in the asymmetric synthesis of bioactive γ-lactams

12:15 – 12:30 | Oral communication 11

• Paulo Paioti – Rapid Synthesis of Diverse Heterocyclic C‒N Atropisomers

12:30 – 12:50 | Blue Danube Junior

• Nejc Petek (University of Ljubljana) - Copper-Catalyzed Synthesis of Vinyl Sulfones and Sulfonamides under Visible Light

12:50 – 14:00 | Lunch

13:40 – 14:40 | Steering Committee meeting

14:00 – 16:00 | Excursion to Chlupáč Anthropological Museum and Minaralogical Museum

16:00 – 18:00 | Boat Cruise at Vltava River

19:00 – 21:00 | Speakers Dinner

Tuesday, August 27, 2024

Chair: Péter Kele

9:00 – 9:45 | Invited Lecture

• Josep Cornella (Max-Planck-Institut für Kohlenforschung) - Innovation in Reagents and Catalysts. From Fundamentals to Immediate Application

9:45 – 10:05 | Blue Danube Junior

• Branislav Ferko (Slovak University of Technology) - Catalytic Enantioselective Nucleophilic Desymmetrization at P(V)

Branislav Ferko (Slovak University of Technology)

10:05 – 10:20 | Oral communication 12

• Rafael Navrátil – Multimetallic Pd- and Ni-Catalyzed C(sp2)–P Cross-Coupling under Aqueous Micellar Conditions

10:20 – 10:35 | Oral communication 13

• Luka Jedlovčnik – Towards Selective Deuteration of Diazine Carboxamides via Directed Ortho Metalation

10:35 – 11:00 | Coffee break

Chair: Radek Cibulka

11:00 – 11:30 | Blue Danube Senior

• Kamil Paruch (Masaryk University, Brno) - Weakly interacting heterocyclic motifs as the basis of highly selective inhibitors of underexplored protein kinases

11:30 – 11:45 | Oral communication 14

• Ondřej Baszczyňski – Phosphorus Self-Immolative Linkers in Prodrug Design

11:45 – 12:00 | Oral communication 15

• Jan Chasák – Squaramides as Mycobacterial ATP synthase Inhibitors: Synthetic Pathways, Biological Evaluation & Mechanism of Action

12:00 – 12:15 | Oral communication 16

• Jerneja Kladnik – Synthesis and Evaluation of Novel Fluorescent Probes for Amyloid β Plaques Imaging

12:15 – 12:30 | Oral communication 17

• Andras Kotschy – Induced proximity by heterocycles: molecular glues and beyond

12:30 – 13:45 | Lunch

Chair: Kamil Paruch

13:45 – 14:05 | Blue Danube Junior

• Jan Vrána (University of Pardubice) - Utilization of Conventional Lewis Acids as Bases: Complexes of Carboranes with N-Heterocyclic Carbenes as Catalysts

14:05 – 14:20 | Oral communication 18

• Florian Rudroff – A concurrent cascade towards unsymmetric pyrazines – a hell of a smell

14:20 – 14:35 | Oral communication 19

• Viktor Iaroshenko – Mechanochemical synthesis of 3-substituted chromones

14:35 – 14:50 | Oral communication 20

• Nina Biedermann – A solvent-free ultra-fast Wittig olefination – Diels Alder reaction sequence in one-pot under mechanochemical conditions

14:50 – 15:35 | Invited Lecture

• Jérôme Lacour (University of Geneva) - Chiral Trityls as Versatile Property and Reactivity Platforms

15:35 – 16:05 | Coffee break

Chair: Ondřej Baszczyňski

16:05 – 16:35 | Blue Danube Senior

• Wolfgang Kroutil (University of Gratz) - Triggering Formation of Heterocycles Using Biocatalysis

16:35 – 16:50 | Oral communication 21

• Márton Ferenc Szlávik – Synthesis of electron deficient alkenes: useful building blocks for heterocycle formation

16:50 – 17:20 | Invited Lecture of the Serbian Representative

• Igor Opsenica (University of Belgrade) Case studies in the chemistry of heterocyclic compounds: 1H-tetrazol-5-amine, pyrazole, pyrimidine and thiophene derivatives

17:20 – 19:00 | Poster session

19:30 – 23:00 | Conference dinner

Wednesday, August 28, 2024

Chair: Wolfgang Kroutil

9:00 – 9:45 | Invited Lecture

• Romano Orru (Maastricht University) - Biomimetic Spirocyclizations for the Synthesis of Indole Alkaloids

9:45 – 10:05 | Blue Danube Junior

• Szilárd Varga (Research Centre for Natural Sciences, Hungary) - From Monoterpene Indole Alkaloids to Thianthrenium Salts: A Bioinspired Journey in Organic Synthesis

10:05 – 10:20 | Oral communication 22

• Peter Gabko – Concise stereoselective synthesis of 5-substituted 1,2-dihydroxyindolizidines and -pyrrolizidines related to natural alkaloids

10:20 – 10:35 | Oral communication 23

• Raju Hazra – Total Synthesis of the Cryptic Secondary Metabolites Acybolins

10:35 – 11:00 | Coffee break

Chair: Martin Kotora

11:00 – 11:30 | Blue Danube Senior

• Jernej Iskra (University of Ljubljana) - From Lignocellulosic Biomass to Vanillin and Cellulose Hydrogels

11:30 – 11:45 | Oral communication 24

• Wim Dehaen – New efficient methods for the synthesis of 1,2,3-triazoles

11:45 – 12:00 | Oral communication 25

• Sándor Balázs Király – Preparation of bridged- and spirocyclic O,N-heterocycles using domino reactions

12:00 – 12:15 | Oral communication 26

• Marko D. Mihovilovic – Employing Heterocycles for Quantification and as Redox-Mediators
  in Laccase-Catalyzed Starch Oxidation

Closing Remarks

List of speakers

Plenary speaker

Lutz Ackermann (Georg-August-University Göttingen)

• Electrocatalyzed C-H Activation with Potential

Invited

Jérôme Lacour (University of Geneva)

• Chiral Trityls as Versatile Property and Reactivity Platforms

Josep Cornella (Max-Planck-Institut für Kohlenforschung)

• Innovation in Reagents and Catalysts. From Fundamentals to Immediate Application

Romano Orru (Maastricht University)

• Biomimetic Spirocyclizations for the Synthesis of Indole Alkaloids

Michal Hocek (Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences)

• Modifications of Heterocyclic Nucleobases in Nucleotides and Nucleic Acids for Applications in Chemical Biology

Blue Danube Senior

Martin Putala

• Design of Oligothienyl Acenes with Electron Withdrawing Groups as n-type Semiconductors

Péter Kele

• Bioorthogonal Modulation of Photoresponsivity and Vice Versa.

Kamil Paruch

• Weakly Interacting Heterocyclic Motifs as the Basis of Highly Selective Inhibitors of Underexplored Protein Kinases

Wolfgang Kroutil

• Triggering Formation of Heterocycles Using Biocatalysis

Jernej Iskra

• From Lignocellulosic Biomass to Vanillin and Cellulose Hydrogels

Blue Danube Junior

Bartholomäus Pieber

• Light-Mediated Nickel Catalysis Enabled by Donor-Acceptor Ligands

Szilárd Varga

• From Monoterpene Indole Alkaloids to Thianthrenium Salts: A Bioinspired Journey in Organic Synthesis

Jan Vrána

• Utilization of Conventional Lewis Acids as Bases: Complexes of Carboranes with N-Heterocyclic Carbenes as Catalysts

Nejc Petek

• Copper-Catalyzed Synthesis of Vinyl Sulfones and Sulfonamides under Visible Light

Branislav Ferko

• Catalytic Enantioselective Nucleophilic Desymmetrization at P(V)

Special Guest

Igor Opsenica (University of Belgrade – Faculty of Chemistry)

• Case studies in the chemistry of heterocyclic compounds: 1H-tetrazol-5-amine, pyrazole, pyrimidine and thiophene derivatives

Meeting Venue

Faculty of Science, Charles University, Prague, Czech Republic

The faculty of Science was founded in 1920 and is located below the historic Vyšehrad site on the right bank of Vltava river.

Address of Symposium Venue

Faculty of Science
Charles University
Albertov 6, 128 00 Praha 2

https://www.natur.cuni.cz/eng

50.0688894N, 14.4244911E

How to get to the Symposium Venue

Symposium Venue is located within walking distance of the tram stop Albertov (most of the trams from Albertov cross Metro lines).

https://www.dpp.cz/en

Committees

Scientific Advisory Board

Andras Kotschy (Servier Research Institute of Medicinal Chemistry, Hungary)

Marko Mihovilovic (Vienna University of Technology, Austria)

Milan Potáček (Masaryk University, Czech Republic)

Michael Schnürch (Vienna University of Technology, Austria)

Branko Stanovnik (University of Ljubljana, Slovenia)

Jakub Švenda (Masaryk University, Czech Republic)

Milata Viktor (Slovak University of Technology, Slovenia)

Local Organizing Committee

Lukáš Rýček (Symposium Chair, Faculty of Science Charles University, Prague)

Radek Cibulka (University of Chemistry and Technology, Prague, VŠCHT)

Martin Kotora (Faculty of Science Charles University, Prague)

Miroslav Soural (Palacky University, Olomouc)

Irena G. Stará (Institute of Organic Chemistry and Biochemistry, Prague)

Jan Veselý (Faculty of Science Charles University, Prague)

Zina Pecková (Congress Business Travel, Prague)

Sponsors and Partners

• Faculty of Science, Charles University

• Department of Organic Chemistry, Faculty of Science, Charles University

• IOCB TEC-H

• Merck

• Servier

• Shimadzu

• Zentiva

20th Blue Danube Symposium on Heterocycles in Chemistry: Partners and Sponsors.

Media partner

• Portály LabRulez

LabRulez: 20th Blue Danube Symposium on Heterocycles in Chemistry media partner.