ICPMS
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike
Author
TU Wien
The TU Wien is Austria's largest research and educational institution in the field of technology and natural sciences. More than 4,000 scientists are researching "technology for people" in five main research areas at eight faculties. The content of the studies offered is derived from the excellent research. More than 26,000 students in 62 degree programmes benefit from this. As a driver of innovation, TU Wien strengthens the business location, facilitates cooperation and contributes to the prosperity of society.
Tags
Article
Scientific article
Science and research
Logo of LinkedIn

Ultra-short light pulses enable high-precision "artificial nose"

We, 19.6.2024
| Original article from: TU Wien/Hongtao Hu and Vinzenz Stummer
A new spectroscopy method has been developed at TU Wien: Using a series of laser pusles, chemical analyses can be carried out much faster and more precisely than before.
- **Photo:** TU Wien: Ultra-short light pulses enable high-precision "artificial nose" - Hongtao Hu and Vinzenz Stummer.
  • Photo: TU Wien: Ultra-short light pulses enable high-precision "artificial nose" - Hongtao Hu and Vinzenz Stummer.

Whether you want to analyze environmental samples in nature or monitor a chemical experiment, you often need highly sensitive sensors that can "sniff out" even tiny traces of a certain gas with extreme accuracy. Variants of Raman spectroscopy are often used for this purpose: Different molecules react in very characteristic ways to light of different wavelengths. If you irradiate a sample with the appropriate light and measure exactly how the light is modified by the sample, you can find out whether the sample contains a certain gas or not.

However, scientists at TU Wien (Vienna) has now taken a significant step forward in this area: a new method has been developed to generate and precisely control suitable light for such experiments. This not only enables much greater accuracy than before, the method also works without moving parts and is therefore much faster than the best technologies to date. The method has now been published in the journal "Light: Science and Applications".

Stimulated Raman emission: wobbling atoms

The basis of the new technology is so-called "stimulated Raman emission" - a quantum physical process in which several photons are involved simultaneously. A sample is irradiated with light that consists of two slightly different wavelengths. A molecule in the sample can therefore be hit simultaneously by two photons that carry slightly different amounts of energy. It can then happen that the high-energy photon and the lower-energy photon suddenly become two lower-energy photons - the remaining energy difference leads to the molecule suddenly having a little more energy than before. The atoms of the molecule can be stimulated to wobble or rotate, for example.

This means that the number of higher-energy photons has decreased and the number of lower-energy photons has increased. This is precisely how you can tell that the molecule you are looking for was actually in the sample.

"Normally, however, this is a laborious process," explains Hongtao Hu from the Institute of Photonics at TU Wien, the first author of the current paper. "You have to carefully try out one wavelength after another - for example, by directing the light at a crystal and then slowly rotating the angle or changing the temperature of the crystal so that the sample is hit by many different wavelengths over time."

TU Wien: Ultra-short light pulses enable high-precision "artificial nose" - Hongtao Hu and Vinzenz Stummer.

Femtosecond laser pulses

At TU Wien, however, Prof. Andrius Baltuska's research group cooperated with Dr. Xinhua Xie from SwissFEL at Paul Scherrer Institute, Switzerland, and Prof. Alexei Zheltikov from the Department of physics and Astonomy at Texas A&M university, USA, to measure the Raman using a special light source. Andrius Baltuska's group had been working on this light source for years. Hongtao Hu and the co-authors have now been able to show through extensive computer simulations that it can achieve much higher precision than conventional methods. "We don't just produce one wavelength, but a series of ultra-short light pulses," explains Prof. Andrius Baltuska. "Each of these pulses has a duration in the femtosecond range."

These light pulse series do not have a specific wavelength - they are made up of many different wavelengths. The decisive factor is the phase of the light waves - i.e. the position of wave crests and troughs. "By changing the phase, we can shift all these wavelengths that make up the pulse a little at the same time," says Hongtao Hu. "You then get a Raman signal at very specific wavelengths, but not at others. Our method therefore allows us to examine a specific wave range in a very elegant way without having to adjust any moving parts. In principle, this allows us to differentiate between very different molecules."

Higher spectral resolution than ever before

Hongtao Hu was able to show: The longer the series of light pulses, the higher the precision: "You can therefore achieve a significantly higher spectral resolution with a series of many individual pulses than ever before," says Hongtao Hu. In principle, it is also possible to distinguish Raman transitions from each other that come from different molecules, whose signals looked almost exactly the same if the spectral resolution is not high enough. Possible applications for the new technology range from environmental analysis to quality assurance in the chemical industry and biological imaging.

TU Wien
 

Related content

Quantifying the Similarity of Two Coffee Bean Products by GC/MS and EDXRF

Applications
| 2024 | Shimadzu
Instrumentation
X-ray, GC/MSD, GC/MS/MS, GC/QQQ, SPME
Manufacturer
Shimadzu
Industries
Food & Agriculture

Multifaceted Evaluation of IgG Glycan Profiles Considering the Components in Glycosyltransferase Reactions

Applications
| 2024 | Shimadzu
Instrumentation
ICP/MS, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

WATER NEEDS IN PHARMA QUALITY CONTROL

Brochures and specifications
| 2019 | ELGA LabWater
Instrumentation
Laboratory instruments
Manufacturer
ELGA LabWater
Industries
Pharma & Biopharma

Elemental Analysis in Yeast Cells and Selenium Enriched Yeast Cells by ICP-MS with Automated Micro-Flow Sample Introduction

Posters
| 2024 | Agilent Technologies (ASMS)
Instrumentation
ICP/MS, ICP/MS/MS
Manufacturer
Elemental Scientific, Agilent Technologies
Industries
Clinical Research

Screening Analysis of 24 Elemental Impurity Elements in Drugs Using ICPMS-2040/2050

Applications
| 2024 | Shimadzu
Instrumentation
ICP/MS
Manufacturer
Shimadzu
Industries
Pharma & Biopharma
 

Related articles


Article | Scientific article

Sugar metabolism is surprisingly conventional in cancer

Study has implications for targeting metabolism in cancer treatment.
Washington University in St. Louis
more

Article | Video

RESEARCHERS SERVE UP AN IMPROVED MODEL OF INDOOR POLLUTION PRODUCED BY COOKING

New approach could inform better public health guidelines.
Johns Hopkins University
more

Article | Video

Why urea may have been the gateway to life

Urea reacts extremely quickly under the conditions that existed when our planet was newly formed. This new insight furthers our understanding of how life on Earth might have begun.
ETH Zürich
more

Article | Video

Scientists at IOCB Prague are developing a new generation of DNA tests for a wide range of applications

A research group led by Dr. Edward Curtis has developed two new types of catalytic DNA molecules (deoxyribozymes) that can reveal the presence of target molecules through fluorescence or color.
Ústav organické chemie a biochemie AV ČR
more
 

Related content

Quantifying the Similarity of Two Coffee Bean Products by GC/MS and EDXRF

Applications
| 2024 | Shimadzu
Instrumentation
X-ray, GC/MSD, GC/MS/MS, GC/QQQ, SPME
Manufacturer
Shimadzu
Industries
Food & Agriculture

Multifaceted Evaluation of IgG Glycan Profiles Considering the Components in Glycosyltransferase Reactions

Applications
| 2024 | Shimadzu
Instrumentation
ICP/MS, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

WATER NEEDS IN PHARMA QUALITY CONTROL

Brochures and specifications
| 2019 | ELGA LabWater
Instrumentation
Laboratory instruments
Manufacturer
ELGA LabWater
Industries
Pharma & Biopharma

Elemental Analysis in Yeast Cells and Selenium Enriched Yeast Cells by ICP-MS with Automated Micro-Flow Sample Introduction

Posters
| 2024 | Agilent Technologies (ASMS)
Instrumentation
ICP/MS, ICP/MS/MS
Manufacturer
Elemental Scientific, Agilent Technologies
Industries
Clinical Research

Screening Analysis of 24 Elemental Impurity Elements in Drugs Using ICPMS-2040/2050

Applications
| 2024 | Shimadzu
Instrumentation
ICP/MS
Manufacturer
Shimadzu
Industries
Pharma & Biopharma
 

Related articles


Article | Scientific article

Sugar metabolism is surprisingly conventional in cancer

Study has implications for targeting metabolism in cancer treatment.
Washington University in St. Louis
more

Article | Video

RESEARCHERS SERVE UP AN IMPROVED MODEL OF INDOOR POLLUTION PRODUCED BY COOKING

New approach could inform better public health guidelines.
Johns Hopkins University
more

Article | Video

Why urea may have been the gateway to life

Urea reacts extremely quickly under the conditions that existed when our planet was newly formed. This new insight furthers our understanding of how life on Earth might have begun.
ETH Zürich
more

Article | Video

Scientists at IOCB Prague are developing a new generation of DNA tests for a wide range of applications

A research group led by Dr. Edward Curtis has developed two new types of catalytic DNA molecules (deoxyribozymes) that can reveal the presence of target molecules through fluorescence or color.
Ústav organické chemie a biochemie AV ČR
more
 

Related content

Quantifying the Similarity of Two Coffee Bean Products by GC/MS and EDXRF

Applications
| 2024 | Shimadzu
Instrumentation
X-ray, GC/MSD, GC/MS/MS, GC/QQQ, SPME
Manufacturer
Shimadzu
Industries
Food & Agriculture

Multifaceted Evaluation of IgG Glycan Profiles Considering the Components in Glycosyltransferase Reactions

Applications
| 2024 | Shimadzu
Instrumentation
ICP/MS, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

WATER NEEDS IN PHARMA QUALITY CONTROL

Brochures and specifications
| 2019 | ELGA LabWater
Instrumentation
Laboratory instruments
Manufacturer
ELGA LabWater
Industries
Pharma & Biopharma

Elemental Analysis in Yeast Cells and Selenium Enriched Yeast Cells by ICP-MS with Automated Micro-Flow Sample Introduction

Posters
| 2024 | Agilent Technologies (ASMS)
Instrumentation
ICP/MS, ICP/MS/MS
Manufacturer
Elemental Scientific, Agilent Technologies
Industries
Clinical Research

Screening Analysis of 24 Elemental Impurity Elements in Drugs Using ICPMS-2040/2050

Applications
| 2024 | Shimadzu
Instrumentation
ICP/MS
Manufacturer
Shimadzu
Industries
Pharma & Biopharma
 

Related articles


Article | Scientific article

Sugar metabolism is surprisingly conventional in cancer

Study has implications for targeting metabolism in cancer treatment.
Washington University in St. Louis
more

Article | Video

RESEARCHERS SERVE UP AN IMPROVED MODEL OF INDOOR POLLUTION PRODUCED BY COOKING

New approach could inform better public health guidelines.
Johns Hopkins University
more

Article | Video

Why urea may have been the gateway to life

Urea reacts extremely quickly under the conditions that existed when our planet was newly formed. This new insight furthers our understanding of how life on Earth might have begun.
ETH Zürich
more

Article | Video

Scientists at IOCB Prague are developing a new generation of DNA tests for a wide range of applications

A research group led by Dr. Edward Curtis has developed two new types of catalytic DNA molecules (deoxyribozymes) that can reveal the presence of target molecules through fluorescence or color.
Ústav organické chemie a biochemie AV ČR
more
 

Related content

Quantifying the Similarity of Two Coffee Bean Products by GC/MS and EDXRF

Applications
| 2024 | Shimadzu
Instrumentation
X-ray, GC/MSD, GC/MS/MS, GC/QQQ, SPME
Manufacturer
Shimadzu
Industries
Food & Agriculture

Multifaceted Evaluation of IgG Glycan Profiles Considering the Components in Glycosyltransferase Reactions

Applications
| 2024 | Shimadzu
Instrumentation
ICP/MS, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Pharma & Biopharma

WATER NEEDS IN PHARMA QUALITY CONTROL

Brochures and specifications
| 2019 | ELGA LabWater
Instrumentation
Laboratory instruments
Manufacturer
ELGA LabWater
Industries
Pharma & Biopharma

Elemental Analysis in Yeast Cells and Selenium Enriched Yeast Cells by ICP-MS with Automated Micro-Flow Sample Introduction

Posters
| 2024 | Agilent Technologies (ASMS)
Instrumentation
ICP/MS, ICP/MS/MS
Manufacturer
Elemental Scientific, Agilent Technologies
Industries
Clinical Research

Screening Analysis of 24 Elemental Impurity Elements in Drugs Using ICPMS-2040/2050

Applications
| 2024 | Shimadzu
Instrumentation
ICP/MS
Manufacturer
Shimadzu
Industries
Pharma & Biopharma
 

Related articles


Article | Scientific article

Sugar metabolism is surprisingly conventional in cancer

Study has implications for targeting metabolism in cancer treatment.
Washington University in St. Louis
more

Article | Video

RESEARCHERS SERVE UP AN IMPROVED MODEL OF INDOOR POLLUTION PRODUCED BY COOKING

New approach could inform better public health guidelines.
Johns Hopkins University
more

Article | Video

Why urea may have been the gateway to life

Urea reacts extremely quickly under the conditions that existed when our planet was newly formed. This new insight furthers our understanding of how life on Earth might have begun.
ETH Zürich
more

Article | Video

Scientists at IOCB Prague are developing a new generation of DNA tests for a wide range of applications

A research group led by Dr. Edward Curtis has developed two new types of catalytic DNA molecules (deoxyribozymes) that can reveal the presence of target molecules through fluorescence or color.
Ústav organické chemie a biochemie AV ČR
more
Other projects
Follow us
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike