<h3>Introduction</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_From_Raw_Signals_to_Reliable_Results_Post_Acquisition_Data_Workflows_in_ICP_Analysis_f7248bb920.jpg" alt="Thermo Fisher Scientific: From Raw Signals to Reliable Results: Post-Acquisition Data Workflows in ICP Analysis" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_From_Raw_Signals_to_Reliable_Results_Post_Acquisition_Data_Workflows_in_ICP_Analysis_f7248bb920.jpg 245w," sizes="100vw" width="1024" height="512">Modern elemental analysis techniques such as ICP-OES and ICP-MS are capable of generating large volumes of highly sensitive, multi-dimensional data in a single analytical run. These technologies are widely used across environmental, pharmaceutical, food, and materials science applications due to their precision and low detection limits. However, while significant emphasis is often placed on method development, instrument optimisation, and sample preparation, the true scientific value of any analysis is ultimately determined during the post-acquisition phase. It is here that raw instrumental signals are processed, interrogated, and validated before being translated into meaningful and defensible results. Whether you are working with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=227&amp;instrumentationItems=84&amp;manufacturerItems=3&amp;search=iCAP+PRO">iCAP PRO ICP-OES</a>, the&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=232&amp;manufacturerItems=3&amp;search=iCAP+MX">iCAP MX ICP-MS</a>, the iCAP 7000 OES, or Qnova ICP-MS systems, the interface and workflow logic remain familiar.<h3>Method</h3>Following data acquisition, analysts must first navigate and organise complex datasets efficiently. Large analytical sequences may contain hundreds of samples, each with multiple analytes, replicates, and quality control elements. Tools such as column sorting and filtering are therefore essential for structured data interrogation. Sorting concentration values, for example, allows rapid identification of extreme values or potential outliers, while filtering by sample type, QC category, or analyte enables targeted investigation of specific data subsets. These tools support not only workflow efficiency but also statistical awareness, helping analysts detect trends, inconsistencies, or anomalies that may otherwise go unnoticed. In parallel, maintaining a complete LabBook history ensures that all changes to methods, calibration parameters, and analytical settings are recorded. This level of traceability is essential for regulatory compliance, particularly in environments operating under ISO standards or Good Laboratory Practice, and it ensures that results can be reproduced and audited with confidence.A fundamental aspect of post-acquisition processing is the application and evaluation of correction models. ICP-based techniques are inherently susceptible to a range of interferences, including background signals, spectral overlaps, and matrix-induced signal suppression or enhancement. Blank subtraction is typically the first correction applied, removing contributions from reagents, solvents, and instrument background. By comparing results with and without blank correction, analysts can assess the significance of background contributions, particularly at low concentration levels. In ICP-OES, Inter-element correction (IEC) addresses spectral interferences by mathematically compensating for overlapping emission lines, which is especially important in complex matrices containing multiple elements.&nbsp;For ICP-MS, correction equations can be similarly implemented to correct for the presence of an isobaric interferences of mass signals.Internal standard (IS) correction is another critical component, used to normalise signal fluctuations caused by instrument drift, variations in sample introduction, or matrix effects. Reviewing data with these corrections toggled on and off provides valuable diagnostic insight, allowing analysts to determine whether corrections are appropriate and whether the underlying method is robust.While processed concentration data is the primary output of most analyses, deeper insight can be gained by examining the underlying signal intensities. Replicate measurements, for instance, provide a direct assessment of analytical precision. Consistent replicate signals indicate stable measurement conditions, whereas significant variation may suggest issues such as sample heterogeneity, nebuliser instability, or matrix interference. Similarly, blank intensities can reveal contamination or insufficient rinsing between samples, often serving as an early indicator of systematic error. In ICP-OES, spectral sub-array views allow analysts to visualise the emission profile around a selected wavelength, enabling verification of peak shape, background correction points, and potential spectral overlaps. In ICP-MS, attention must be given to detector behaviour, particularly when signals transition between pulse and analog modes at higher concentrations. Such transitions can introduce non-linearity into calibration curves, sometimes necessitating cross-calibration to maintain quantitative accuracy.Calibration is central to transforming raw signal intensity into quantitative concentration data, and its evaluation is one of the most critical steps in the workflow. Several performance indicators are used to assess calibration quality. The coefficient of determination (R²) provides a measure of how well the calibration model fits the data, though a high R² alone does not guarantee accuracy. Bias offers insight into systematic deviations between expected and measured values, highlighting potential issues with standards or instrument response. Detection limits, including the limit of detection (LOD) and instrument detection limit (IDL), define the sensitivity of the method, while background equivalent concentration (BEC) reflects the contribution of background signal to the overall measurement. A comprehensive calibration assessment requires consideration of all these parameters together, rather than reliance on a single metric. In addition, quality control samples—such as calibration check standards (CCVs), certified reference materials (CRMs), and matrix spikes—are used to verify accuracy and method performance. Automated flagging of QC results that fall outside predefined acceptance criteria provides an efficient means of identifying non-compliant data and supports rapid decision-making.Equally important is the evaluation of instrument performance through diagnostic readbacks recorded during the analysis. These parameters provide insight into the physical and operational state of the instrument at the time of measurement. For ICP-MS, key readbacks include nebuliser gas pressure, vacuum levels, and interface conditions. Changes in these parameters can indicate issues such as partial blockages, salt deposition, or vacuum degradation. Similarly, plasma-related parameters and gas flow stability are critical indicators in both ICP-OES and ICP-MS systems. By correlating readback trends with analytical results, analysts can identify the root causes of anomalies, distinguish between instrument-related and sample-related issues, and take corrective action where necessary. This diagnostic capability is particularly valuable when troubleshooting unexpected results or when sharing data with technical support teams for further investigation.Once the data has been thoroughly reviewed and validated, the final step is to export and communicate the results in a clear and usable format. Structured reporting tools enable the generation of comprehensive summaries that include concentration data, calibration details, quality control results, and any associated flags or annotations. These reports are essential for documentation, regulatory submissions, and communication with stakeholders. For greater flexibility, exporting data in CSV format allows integration with external tools such as spreadsheet software, statistical analysis platforms, or laboratory information management systems (LIMS). This interoperability facilitates advanced data analysis, long-term data storage, and seamless integration into broader laboratory workflows.<h3>Conclusion</h3>In conclusion, post-acquisition data processing is not merely a procedural step but a critical component of the analytical workflow that determines the reliability and scientific validity of results. Through careful organisation of data, rigorous application of correction models, detailed evaluation of calibration performance, and continuous monitoring of instrument diagnostics, analysts can ensure that their results are both accurate and defensible. As analytical technologies continue to evolve and datasets become increasingly complex, the importance of robust and systematic data evaluation will only grow. Mastery of these workflows transforms raw instrumental signals into high-quality scientific information, underpinning confident decision-making across a wide range of applications.<h3>Acknowledgement</h3>I would like to thank&nbsp;Matthew Gregory&nbsp;Field Applications Scientist, North EMEA, Trace Elemental Analysis and&nbsp;David Fishwick&nbsp;Field Applications Scientist, North EMEA, Trace Elemental Analysis for the support on this blog and the webinars.Sign up for our webinars live and on demand.English<ul><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5795">Lunch and Learn Tips and Tricks Series: Qtegra Part 1</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5976">Lunch and Learn Tips and Tricks Series: Qtegra Part 2</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5977">Lunch and Learn Tips and Tricks Series: Trace Elemental Analysis (ICP-OES &amp; ICP-MS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5978">Trace Elemental Analysis: Ask the Expert</a></li></ul>Deutsch<ul><li>19. März 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179134/393E071E3B501943730958BA6203F477">Interne Standards in der ICP-OES: Ein Praxisguide für zuverlässige Qualitätssicherung im Labor</a></li><li>18. Juni 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179292/AE4C576B6A54D1AC182F7F77573D380F">Fehler reduzieren, Durchsatz steigern: Autoverdünnung mit PrepFast am ICP-MS</a></li><li>17. September 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179423/B5019C560431BADCA2A76E54E4EFE56F">ICP-OES smarter nutzen: Probendurchsatz erhöhen, Ressourcen sparen</a></li><li>17. Dezember 2026 <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/5179530/94EEDD1F56138F5EEE2AF24E29E6C12A">Qtegra ISDS Software Unlocked – Live im Expertengespräch</a></li></ul><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#AnalyticalChemistry #ICPMS #ICPOES #DataAnalysis</blockquote>

From Raw Signals to Reliable Results: Post-Acquisition Data Workflows in ICP Analysis

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 18th May 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you brochure by MILESTONE and application notes by Shimadzu and Thermo Fisher Scientific!<h3>1. MILESTONE: <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?search=ETHOS+LEAN+">ETHOS™ LEAN</a> Compact Microwave Labstation</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Brochure_ETHOS_LEAN_1_c80f4403a4.pdf">Full PDF for download</a></li></ul>Sample preparation is the foundation of many analytical workflows, and often the most critical step. In elemental analysis, proper digestion ensures accurate and reproducible results with AAS, ICP, and ICP-MS by enabling complete recovery of target elements, minimizing interferences, and reducing blanks. With over 35 years of innovation and more than 30,000 microwave systems installed worldwide, Milestone is a global leader in microwave sample preparation. The ETHOS LEAN, now in its 2nd series, represents this expertise: a compact, affordable labstation delivering full digestion capabilities without compromise. Beyond digestion, ETHOS LEAN supports solvent extraction for chromatography, solvent-free extraction of natural products, and even microwave synthesis workflows, offering unmatched versatility in its class. Selecting the right system is more than a purchase decision: it’s choosing a partner. With Milestone, you gain not only proven technology but also the knowledge and support to ensure long-term success.<h4>BUILT FOR MORE THAN DIGESTION</h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?search=ETHOS+LEAN+">ETHOS LEAN</a> goes beyond digestion. As a compact Microwave Labstation, it supports a suite of accessories that expand its capabilities into multiple workflows. Microwave technology provides a faster, cleaner, and more efficient alternative to conventional sample preparation techniques, reducing processing time, simplifying operations, and minimizing reagent consumption.&nbsp;<h5>Solvent extraction</h5>Closed-vessel microwave technology streamlines extraction for chromatographic analysis, dramatically reducing solvent use and cutting analysis times. Ideal for organic pollutant extraction from environmental samples or fat determination in food and feed.<h5>Solvent-free extraction</h5>Patented Milestone technology enables fast and efficient essential oil extraction in just minutes, preserving aroma and natural composition while minimizing degradation. Selective heating promotes a quicker, more efficient release from plant cells.<h5>Microwave synthesis</h5>Microwave synthesis is a safer and faster alternative to heating mantles or complex reactors, enabling rapid optimization of conditions. Its speed supports research projects and allows practical teaching sessions within standard class times.<h5>High-temperature processes</h5>With the ultraFAST accessory, ETHOS LEAN reaches 1200 °C in just minutes, transforming into a microwave furnace for demanding high-temperature applications such as inorganic synthesis, fusion, or fire assay.<h3>2. Shimadzu: Discriminating between Microsamples of Similar Resins with a Combination of FTIR and Thermal Analysis Instruments</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01114_en_a9291de45e.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>Using the ATR method with FTIR spectroscopy enables simple and rapid qualitative analysis of polymers.</li><li>DSC analysis may be able to reveal differences in polymer thermal histories that cannot be confirmed by FTIR alone.</li><li>TG-DTA can be used to confirm the content level of inorganic additives in polymers</li></ul>A wide range of polymer resins is used in modern society for diverse applications, resulting in increasing demand for qualitative analysis of resin microsamples, such as identifying resin contaminants in products or qualitatively evaluating microplastics for environmental impact assessments. FTIR spectrophotometers are commonly used for qualitative analysis of polymers. In particular, the ATR (attenuated total reflectance) method is widely used because measurements can be performed simply and quickly by clamping a sample against a prism to ensure close contact.&nbsp;While the ATR method makes it relatively easy to discriminate between different types of polymers, clear differences may not appear when analyzing similar polymers—for example, when there are only slight differences in the type or content of additives or the thermal histories during manufacturing. In such cases, differences may be confirmed by using thermal analysis instruments, such as a DSC or TG-DTA system.&nbsp;This article describes an example in which three instruments— an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=IRSpirit-TX">IRSpirit-TX</a> FTIR spectrophotometer, a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=DSC-60+Plus">DSC-60 Plus</a> differential scanning calorimeter, and a DTG-60 simultaneous DTA-TG unit (Fig. 1)—were used to confirm differences among six microsamples of polypropylene (PP) resin.<h4>Conclusion</h4>Details of the six types of PP resin identified from the above measurement results are shown in Table 4. The results indicate that by using an FTIR spectrophotometer in combination with thermal analysis equipment, such as DSC and TG-DTA systems, it is possible to distinguish between minute amounts of the same type of resin with various different properties.<h3>3. Thermo Fisher Scientific: XPS depth profiling of advanced solar cells with femtosecond laser ablation</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/xps_depth_profiling_advanced_solar_cells_appnote_7bda4471a5.pdf">Full PDF for download</a></li></ul>Perovskites are an emerging class of materials in the solar cell industry, exhibiting a number of promising properties, such as improved efficiency and weight, compared to traditional silicon-based devices. X-ray photoelectron spectroscopy (XPS) is an established tool in solar cell research due to its ability to provide extremely surface-sensitive information about elemental composition along with chemical and electronic states.¹ XPS is ultimately a surface analysis technique, however, and in order to assess the full composition of complex, multi-layered structures such as solar cells, a technique known as depth profiling is necessary, which performs multiple rounds of successive material removal and analysis.&nbsp;This application note explores a recent study by Chandler et al. that focuses on solar cells designed for aerospace applications,² where accurate determination of the “true” starting composition of the stacks is essential for tests that simulate space conditions, such as radiation exposure. Without a reliable baseline, it becomes impossible to distinguish between changes induced by the experimental conditions and artifacts introduced during analysis. Conventional ion beam sputtering methods used for depth profiling are known to distort chemical information for perovskites; femtosecond laser ablation (fs-LA) is presented as a novel, alternative method that helps to preserve vital chemical information.<h4>Experimental</h4>A halide-perovskite-based solar cell was fabricated on an ITO/SnO₂ substrate using a spin coating method; the structure of the layers is shown in Figure 1.Analysis was performed with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2206">Thermo Scientific™ Hypulse™ Surface Analysis System</a>, which is equipped with both traditional ion-beam sputtering and femtosecond-laser ablation capabilities. XPS data was collected in SnapShot acquisition mode using an X-ray spot size of 30-200 µm, depending on the method of depth profiling.&nbsp;A MAGCIS ion gun was employed for the sputter depth profiles, generating either a 500 eV monatomic Ar⁺ beam or 8 keV Ar₁₅₀⁺ clusters. The fs-LA depth profiles were generated using a 1,030 nm wavelength laser operating at a 160 fs pulse length. The pulse energy was increased from 42 µJ to 167 µJ when transitioning from the perovskite layer into the substrate structure. A flood gun was employed for charge neutralization during profiling.<h4>Summary&nbsp;</h4>This study confirms the challenges associated with traditional ion sputtering (both monatomic and cluster) for the depth profiling of perovskite-based solar cells. These methods cause preferential sputtering, particularly of lighter elements like carbon, nitrogen, and iodine, which distorts elemental ratios in the profiles and results in artificial signals, such as the formation of metallic lead (Pb⁰). Depth profiling with femtosecond laser ablation represents a novel and robust alternative that preserves the original chemical composition and oxidation states throughout the perovskite layer. By avoiding preferential removal effects, accurate compositional information is maintained during the profile, and erroneous peak signals associated with chemical reduction are eliminated. These factors are vital in establishing a chemically undisturbed baseline before performing tests that simulate environmental effects on the solar cells.&nbsp;With fs-LA depth profiling, any induced changes can be confidently delineated from analytical artifacts, and researchers can better understand and mitigate environmental effects on solar-cell performance, eventually leading to improved solar technologies for aerospace applications.

News from LabRulezICPMS Library - Week 21, 2026

In February of this year, a GAČR project focused on high-speed scanning probe microscopy was launched. Over the next three years, scientists from CEITEC Brno University of Technology (BUT), in collaboration with the Czech Metrology Institute (CMI), will work to accelerate measurement processes using this technique and to improve the analysis of the acquired data with the help of custom-developed artificial intelligence algorithms. The research results will find applications in both scientific and industrial practice, for example, in monitoring live cells or in chip manufacturing.High-speed atomic force microscopy is a field that allows scientists to study the properties of surfaces of various materials. They use microscopes equipped with a miniature tip and probe only a few nanometers (a millionth of a millimeter) in size, which repeatedly glide along regular paths across the sample surface. The scanned area is on the order of micrometers – smaller than a human red blood cell – and the surface shape is recorded with precision comparable to the distance between individual atoms. The probe scans the surface, enabling scientists to obtain highly detailed images with extremely high resolution. Such measurements usually take only a few minutes, but even that can be too long in some cases,&nbsp;especially for samples that change over time, such as living biological materials, as well as non-living materials whose changes are of interest. Addressing this challenge is the core of the GAČR project, officially titled High-Speed Atomic Force Microscopy with Sparse Sampling.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_BUT_CEITEC_Scientists_Aim_to_Increase_High_Speed_Microscopy_Up_to_Fivefold_a30ca0e27e.jpeg" alt="CEITEC BUT: CEITEC Scientists Aim to Increase &quot;High-Speed Microscopy&quot; Up to Fivefold " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_BUT_CEITEC_Scientists_Aim_to_Increase_High_Speed_Microscopy_Up_to_Fivefold_a30ca0e27e.jpeg 150w," sizes="100vw" width="1600" height="1666">“Our joint work aims to speed up the scanning process by optimizing the path along which the microscope tip moves, so that only truly useful data is measured. At the same time, we want to develop an algorithm capable of evaluating images without the need for an intermediate step of reconstructing data from the omitted parts of the surface,” says principal investigator Petr Klapetek from the Czech Metrology Institute (CMI). He points out that conventional high-speed scanning produces hundreds of images across the entire surface, but for samples that change rapidly over time, the probe may miss the area of interest at a critical moment. Changes occurring within milliseconds may therefore not be captured continuously, and important details can be lost. Researchers worldwide have been seeking ways to speed up scanning, usually by modifying microscopes so that the tip moves faster. However, mechanical acceleration increases error rates, for example, due to excessive vibrations. “Since we are aware of the inherent limits of scanning microscopy, we decided to take a completely different approach and tackle the problem through smarter measurement rather than major hardware modifications,”&nbsp;Petr&nbsp;adds.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_BUT_CEITEC_Scientists_Aim_to_Increase_High_Speed_Microscopy_Up_to_Fivefold_3_86682e0c39.jpeg" alt="CEITEC BUT: CEITEC Scientists Aim to Increase &quot;High-Speed Microscopy&quot; Up to Fivefold " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_BUT_CEITEC_Scientists_Aim_to_Increase_High_Speed_Microscopy_Up_to_Fivefold_3_86682e0c39.jpeg 208w," sizes="100vw" width="1600" height="1200"><h4>Software-based acceleration to overcome design limits</h4>One of the main tasks of the project will therefore be to design new scanning paths. These will remain regular but will be arranged in entirely different patterns to maximize the amount of information obtained in minimal time. Combined with more efficient data processing, this approach could increase scanning speed by up to five times. “Data processing is absolutely crucial for us. We need to develop AI algorithms capable of analyzing and interpreting images directly from such sparsely sampled grids, without needing to know what happened in the unmeasured areas. That will likely be our biggest challenge,” adds co-investigator David Nečas from CEITEC BUT. CEITEC BUT will be responsible for designing the scanning patterns and developing the necessary mathematical methods, while the experimental part – including all measurements and testing – will take place at the CMI.The outcome of this three-year collaboration should be a comprehensive theoretical methodology supported by experimental procedures. It could be used, for example, in biological laboratories studying changes in the behaviour of living samples – typically cells – over time. It may also find applications in semiconductor labs, where high-speed scanning microscopy is used mainly for quality control and defect detection during chip production. The method can measure not only the shape and surface structure of a sample, but also its electrical and other properties. “In practice, it could eventually become part of specialized industrial applications, where high-speed scanning microscopes perform imaging and evaluation almost in real time within inspection lines,” concludes David Nečas.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_BUT_CEITEC_Scientists_Aim_to_Increase_High_Speed_Microscopy_Up_to_Fivefold_2_de02ff2fb2.jpeg" alt="CEITEC BUT: CEITEC Scientists Aim to Increase &quot;High-Speed Microscopy&quot; Up to Fivefold " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_BUT_CEITEC_Scientists_Aim_to_Increase_High_Speed_Microscopy_Up_to_Fivefold_2_de02ff2fb2.jpeg 208w," sizes="100vw" width="1600" height="1200"><blockquote>Brno University of Technology is also currently collaborating with the <a target="_blank" rel="noopener noreferrer" href="https://cmi.gov.cz/?language=en">Czech Metrology Institute</a> and other academic and industrial partners on the European project <a target="_blank" rel="noopener noreferrer" href="https://www.ptb.de/epm2024/dinamo/project">DINAMO</a>, which focuses on developing data-processing methods for calibrating all types of scanning probe microscopes. The team at BUT, led by principal investigator David Nečas, is working on standardizing these methods so that even scientists who are not specialists in this type of microscopy can easily set up the instruments themselves and measure their samples as accurately as possible.</blockquote>

CEITEC Scientists Aim to Increase "High-Speed Microscopy" Up to Fivefold 

Article

Application

Academy

Science and research

Video

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Metrohm

Agilent Technologies

Bruker

SelectScience

C&EN

Can the TopScan 4300 FTIR test liquid? What is the detection limit of the 4300 FTIR? Is ambient light an issue for Vaya Raman spectrometer?
Lets discuss some of the most common questions about Agilent Handheld spectrometers.
<blockquote>
Presenter: Yanqia Wang, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Dr. Yanqia Wang started working for Agilent Technologies Inc. as a FTIR application Engineer in 2013, providing pre-&amp;post-sale application support. The products he covers from Bench-top FTIR microscopes to various Mobile FTIR spectrometers. Dr. Wang received his PhD of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing Tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research &amp; development.
</blockquote>

Agilent Technologies: Common Handheld FTIR and Raman Questions Answered

Common Handheld FTIR and Raman Questions Answered

Lets discuss some of the most common questions about Agilent Handheld spectrometers.

Real-time analytics using in-line and on-line technologies provide valuable insights into bioprocess parameters and cell-feeding strategies. Leveraging Process Analytical Technology (PAT), bioproduction processes can be optimized to deliver exceptional results. This includes developing scalable and transferrable processes in monoclonal antibody (mAb) bioproduction. PAT is a game-changer in the bioproduction industry, empowering manufacturers to stay ahead in a highly competitive market.
In this webinar, Dr. Nimesh Khadka, a senior R&amp;D scientist at Thermo Fisher Scientific, will discuss how PAT in bioproduction is revolutionizing how premium products can be developed and manufactured. He will also explore the benefits of the implementation of PAT in bioproduction, including improved process efficiency, reduced manufacturing costs, and the ability to deliver high-quality products consistently.
<h5>Key learning objectives</h5>
<ul>
<li>Learn what the advantages are of Raman Spectroscopy as Process Analytical Technology (PAT)</li>
<li>Explore case studies that show the implementation of Raman as PAT for upstream and downstream processes</li>
<li>Understand how to use chemometrics as a tool to extract useful information from the complex matrix</li>
<li>Discover how the Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer is a reliable, scalable, and accurate instrument with minimum inter-instrument variability allowing model transferability across instruments</li>
</ul>
<h5>Who should attend?</h5>
<ul>
<li>Process engineers</li>
<li>PAT scientists</li>
<li>Process development &amp; team leaders</li>
<li>R&amp;D team leaders</li>
<li>Process improvement champions</li>
<li>Those working in cell culture/bioproduction</li>
</ul>
<h5>Certificate of attendance</h5>
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
<blockquote>
Presenter: Dr. Nimesh Khadka (Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dr. Nimesh Khadka is a senior R&amp;D scientist with the Field Safety Instruments at Thermo Fisher Scientific, specializing in analytical biochemistry, spectroscopy, and chemometrics. He currently champions Raman spectroscopy as process analytical technology (PAT) for developing protein and nucleic acids therapeutics. He completed his Ph.D. at Utah State University, focusing on enzymology, spectroscopy, and alternative bio-energy. His postdoctoral training was conducted at Case Western Reserve University, where he dedicated his research to studying structural biology in biomolecules associated with eye pathologies. As an active member of the American Chemical Society, he remains at the forefront of emerging technologies and is committed to driving innovation to meet customer’s needs.
</blockquote>
<blockquote>
Presenter: Will Thompson (SelectScience)
</blockquote>
<blockquote>
Will studied Biology at the University of Bristol, UK, and as a member of the Editorial team, he now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: Unlocking the Potential: Raman Spectroscopy as Real-time Process Analytical Technology (PAT) for Automation and Enhanced Bioproduction

Unlocking the Potential: Raman Spectroscopy as Real-time Process Analytical Technology (PAT) for Automation and Enhanced Bioproduction

In this webinar, we will discuss how PAT in bioproduction is revolutionizing how premium products can be developed and manufactured.

Raman Spectroscopy as Process Analytical Technology

Incoming materials inspection, or <a href="https://icpms.labrulez.com/webinars?search=raw+materials+identification+RMID">raw materials identification</a> (RMID), is critical to the production of high-quality industrial products. 
While spectroscopic RMID tests are often used in the chemical industry, they are less common in the polymer industry because many of the samples are not well-suited to commonly deployed technologies like <a href="https://icpms.labrulez.com/webinars?search=Raman">Raman</a> and <a href="https://icpms.labrulez.com/webinars?search=FTIR">FTIR</a>. This forces companies to either trust the label or rely on traditional wet-chemical tests for materials testing.
During this webinar, Omar Sallouh, Head of Quality Assurance &amp; Process Engineering at Rampf Polymer Solutions GmbH &amp; Co. Kg presents a faster and safer approach for quality testing of polyols, isocyanates and silicones. He has successfully implemented <a href="https://icpms.labrulez.com/webinar/2266">Near-Infrared</a> (NIR) spectroscopy in the QC laboratory to rapidly identify incoming materials and quantify their critical quality attributes.
Mr. Sallouh joins Dr. Adam J. Hopkins, Spectroscopy Product Manager at Metrohm USA, who will give a brief introduction to NIR, focusing on its advantages for material identification and comparing with alternative technologies. The event closes with a Q&amp;A session to address any questions asked during and after the webinar.
<blockquote>
Presenter: Omar Sallouh, M.Sc. (Head of QA &amp; Process Engineering, Rampf Polymer Solutions GmbH &amp; Co. KG)
</blockquote>
<blockquote>
Omar Sallouh has been working for RAMPF Polymer Solutions since 2018. He is responsible for Quality Assurance and Process Engineering.
</blockquote>
<blockquote>
He has a Master of Science in Chemistry from the Technical University of Dortmund.
</blockquote>
<blockquote>
Presenter: Adam J. Hopkins, PhD (Spectroscopy Product Manager, Metrohm USA)
</blockquote>
<blockquote>
Dr. Adam J. Hopkins has nearly 20 years of experience as a spectroscopist. He got his Ph.D. in chemistry from the University of Oregon where he studied nonlinear optical spectroscopy under Geraldine Richmond. Prior to joining Metrohm USA, Adam worked developing spectroscopic solutions for standoff and noncontact sensing applications using Laser Induced Breakdown and Raman spectroscopy. Dr. Hopkins is a member of the American Chemical Society, Society for Applied Spectroscopy, Coblentz Society, and SPIE. He is the author of 19 papers and proceedings and is the author of three patents.
</blockquote>

Metrohm: Guaranteeing Product Quality: NIR Inspection of Polyols, Isocyanates and Silicones

Guaranteeing Product Quality: NIR Inspection of Polyols, Isocyanates and Silicones

Faster and safer approach for quality testing of polyols, isocyanates and silicones using Near-Infrared (NIR) spectroscopy

NIR Inspection of Polyols, Isocyanates and Silicones

Join our expert application scientist to learn about the&nbsp;new features available in the TruScan G3 for pharmaceutical and biotechnology manufacturing QA/QC.Discover how the new Thermo Scientific™ TruScan™ G3 Handheld Raman Analyzer uses Raman spectroscopy to perform accurate and reliable material identification at the point of need, minimizing the need for costly and time-consuming laboratory sampling tests.<h4>You will learn:</h4><ul><li>How to stay compliant with 21CFR Part11 requirements</li><li>The backwards compatibility with Thermo Scientific™ TruScan™ RM methods</li><li>The patented superior algorithm</li><li>New features and capabilities available in the TruScan G3</li></ul><h5>Who should attend:</h5><ul><li>Quality Control Professionals</li><li>Process Analytics Professionals</li><li>Quality Assurance Professionals</li></ul><blockquote>Presenter: Kathy RosalinaKathy Rosalina is a Product Applications Engineer at Thermo Fisher Scientific, responsible for the technical and applications support for Portable Analytical Instruments in raw materials verification, counterfeit detection, and PAT control. Kathy has a decade of experience in the use of vibrational spectroscopy and chemometric analysis for a wide range of application areas in pharma, biotech, and chemical industries. She has extensive knowledge in implementation and validation of handheld instruments in pharmaceutical customers.</blockquote>

Thermo Scientific: Discover the next generation of raw material ID testing for QA/QC

Discover the next generation of raw material ID testing for QA/QC

Learn about the new features available in the TruScan G3 for pharmaceutical and biotechnology manufacturing QA/QC.

Discover the next generation of raw material ID testing

The global pharmaceutical market's growth has led to an alarming increase in substandard and falsified (SF) medicines, posing significant risks to public health.These dangerous products compromise patient safety and treatment efficacy, particularly in critical areas, such as antimalarials and antibiotics. Rapid, accurate detection methods are essential to combat this growing threat and ensure medication integrity across various settings, from pharmacies to field inspections.In this webinar, Drs. Basant Giri (Kathmandu Institute of Applied Sciences) and Toni Barstis (Saint Mary’s College) will share insights about their collaboration in Nepal where there were 346 drug recalls during the period from 2010 through 2020, with approximately 75% of those being substandard or falsified. Giri and Barstis are using novel paper-based devices and a handheld Raman spectrometer for field-expedient testing and more advanced method development. They will demonstrate how these tools can work together to improve the safety and efficacy of pharmaceuticals and the safety of consumer products. Adam Hopkins, Spectroscopy Product Manager from Metrohm USA, will briefly discuss the unique features of the MIRA handheld Raman analyzer that make it ideal for this critical work<h4>Key Learning Objectives:</h4><ul><li>Insight into the sacle of the SF medicine problem: Information crucial for audience to understand the scope of the issue and its potential impact on their operations and reputation</li><li>The underlying science behind field-expedient testing methods: Knowledge is relevant for QA teams and forensic chemists who need to implement or improve field-testing protocols</li><li>Discover a practical example of how to apply Raman in a real-world setting: Benefits those involved with global supply chain management and international quality assurance efforts</li><li>Technological advancements in handheld Raman: Helps decision-makers considering investments in new quality control equipment</li></ul><h4>Who Should Attend:</h4><ul><li>VPs and Chiefs of Product Quality</li><li>Quality assurance and management team members and leads</li><li>Supply chain managers</li><li>Forensic chemists and scientists</li><li>Anyone involved in or curious about pharmacovigilance activities</li></ul><blockquote>Presenter: Dr. Basant Giri (Senior Scientist, Kathmandu Institute of Applied Sciences)Presenter:&nbsp;Dr. Toni L.O. Barstis (Professor Emeritus, Saint Mary’s College, Notre Dame, IN)Presenter:&nbsp;Dr. Adam J. Hopkins (Spectroscopy Product Manager, Metrohm USA)Presenter:&nbsp;Ann Thayer (Contributing Editor, C&amp;EN Media Group)</blockquote>

C&EN: In-field Identification of Low-Quality Medicines using Handheld Raman

In-field Identification of Low-Quality Medicines using Handheld Raman

The global pharmaceutical market's growth has led to an alarming increase in substandard and falsified (SF) medicines.

In-field Identification of Low-Quality Medicines

Switching to a portable Raman device that can read through both transparent and non-transparent containers will help you move towards “zero waste”, drastically reduce sampling and associated costs, and increase productivity.&nbsp;The Agilent Raman Raw Material Identity Verification System (Vaya) enables zero-waste workflows with its new unique spatial shift Raman spectroscopy (SORS) technology, enabling raw materials to be verified through opaque and transparent containers. This unique innovation eliminates the need to sample most raw materials, significantly reducing unnecessary waste of time, personnel, and materials. Additionally, Vaya has received the Accountability, Consistency and Transparency (ACT) label certification from My Green Lab, highlighting the development and life cycle of environmentally friendly products.Key learning objectives: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Discover how we can identify materials through transparent and non-transparent packaging.</li><li style="tab-stops:list 36.0pt;">Learn how to build a robust method to avoid false positive identifications.</li><li style="tab-stops:list 36.0pt;">See how you can drastically reduce your consumables.</li></ul><blockquote>Presenter: &nbsp;Rob Wills (Molecular Spectroscopy Specialist, Agilent Technologies)Rob joined Agilent Technologies in March 2011 as Product Specialist for Molecular Spectroscopy covering UK, Ireland and Nordics. He has a wealth of technical and business experience accumulated over 30 years in the laboratory instrumentation business, during which time he has held a variety of roles. In his current role he acts as the technical liaison between the end user customer and the sales team, advising and creating solutions based on Agilent’s spectroscopy range that help give our customers the trusted answers they need and the valued insights they seek.</blockquote>

Agilent: Raw Material ID Through Non-Transparent Packaging Using Agilent Vaya Handheld Raman

Raw Material ID Through Non-Transparent Packaging Using Agilent Vaya Handheld Raman

If you regularly receive a large number of raw materials from a variety of suppliers at a high frequency, this webinar is for you!

Raw Material ID Using Agilent Vaya Raman

A real bottleneck in GMP environments can be the verification and release of incoming raw materials. Agilent's Raman systems for raw material identification can alleviate this by making measurements through opaque containers using spatially offset Raman spectroscopy (SORS).&nbsp;We will discuss Agilent's handheld Vaya and mobile RapID solutions as well as demonstrate the Vaya's capabilities.<blockquote>Presener: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.</blockquote>

Agilent Technologies: Advance Your Raw Material ID: How Handheld Raman Can Verify Materials Through Opaque Packaging

Advance Your Raw Material ID: How Handheld Raman Can Verify Materials Through Opaque Packaging

We will discuss Agilent's handheld Vaya and mobile RapID solutions as well as demonstrate the Vaya's capabilities.

Handheld Raman: Verifying Materials Through Opaque Packaging

Fourier transform infrared (FTIR) spectroscopy is a well-established and powerful instrumental technique, with FTIR analysis providing detailed information on the composition of solid, liquid, and gaseous samples. Developing models for FTIR quantitative analysis is simple using the a Cary 630 FTIR spectrometer and MicroLab FTIR software.<blockquote>Presenter: Yanqia Wang, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)Dr. Yanqia Wang started working for Agilent Technologies Inc. as a FTIR application Engineer in 2013, providing pre-&amp;post-sale application support. The products he covers from Bench-top FTIR microscopes to various Mobile FTIR spectrometers. Dr. Wang received his PhD of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing Tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research &amp; development.</blockquote>

Agilent Technologies: Optimize your FTIR, UV-Vis-NIR, Raman, Imaging, and Fluorescence Workflows

Quantitation Modeling for FTIR and Raman Measurements

Learn about developing models for FTIR quantitative analysis by Cary 630 FTIR spectrometer and MicroLab FTIR software.

In this webinar, participants will gain valuable insights intro Bruker’s innovation solutions tailored for the Pharmaceutical Industry. The session will commence with an introduction to Bruker, highlighting the company’s expertise and commitment to deliver cutting-edge solutions for Pharma. The webinar will then delve into FT-IR products, elucidating their applications and benefits within the pharmaceutical sector. Furthermore, attendees will explore the use of handheld Raman product, understanding how the portable device is capable to offer rapid and reliable results.&nbsp;The webinar will also shed light on FT-NIR technology, especially its role in ensuring content uniformity and facilitating Process Analytical Control (PAT) in pharmaceutical manufacturing. Lastly, the session will emphasize the compliance of Bruker products with the stringent requirements of the Pharmaceutical Industry, showcasing their adherence to quality standards and regulations.In this Webinar You Will Learn:<ul><li>FT-IR Spectroscopy for Pharma Industry</li><li>Handheld Raman Spectroscopy for QC</li><li>FT-NIR for Content Uniformity and Process Analytical Control (PAT)</li><li>Compliance to Pharma Regulations</li><li>Q&amp;A</li></ul><blockquote>Presenter: Mr. Mario EckPresenter: Dr. Felix FrommPresenter: Dr. Mui Saranwong</blockquote>

Bruker: Mastering Quality Control: The Power of FT-IR/NIR and Raman Spectroscopy for Pharmacopeia Compliance.

Mastering Quality Control: The Power of FT-IR/NIR and Raman Spectroscopy for Pharmacopeia Compliance.

In this webinar, participants will gain valuable insights intro Bruker’s innovation solutions tailored for the Pharmaceutical Industry. 

FT-IR/NIR and Raman Spectroscopy for Pharmacopeia Compliance

<div>This webinar introduces scattering scanning nearfield optical microscopy (s-SNOM), which provides&nbsp;information about the complex optical properties of the nanoscale region of a sample under a metallized tip that nanofocuses optical radiation. Recent developments in novel methods, advanced light sources, and refined instrumentation have made s-SNOM more valuable and accessible.Capabilities for s-SNOM are available on Bruker’s <a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/products-and-solutions/infrared-and-raman/nanoscale-infrared-spectrometers/anasys-nanoir3-s.html">nanoIR3-s</a> and <a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/products-and-solutions/infrared-and-raman/nanoscale-infrared-spectrometers/anasys-nanoir3-s-broadband.html">nanoIR3-s Broadband</a> platforms, and the technique itself was developed in collaboration with the webinar’s guest speaker, Professor Markus Raschke, Dept. of Physics/JILA, University of Colorado.After a thorough and illustrative introduction to the method, Prof. Raschke presents his research efforts towards using s-SNOM, this new dimension in optical nanoprobe imaging, to access the functional properties of materials and systems including electronic materials, energy materials, nano-biomaterials, quantum systems, and more.Following Prof. Raschke’s comprehensive presentation, he answers questions from the audience covering topics from the maximum sensitivity level of s-SNOM to the use of complementary AFM techniques with s-SNOM.&nbsp;</div>

Bruker: Recent Advancements in Infrared Nano-imaging with Nano-FTIR Spectroscopy

Recent Advancements in Infrared Nano-imaging with Nano-FTIR Spectroscopy

Learn how s-SNOM advances understanding of the functional properties of materials