TOC Calibration, System Suitability, and Verification: Ensuring Accuracy and Compliance in Water Quality Analysis

Mastering Total Organic Carbon (TOC) Analysis

From Fundamentals to Compliance and Long-Term Performance

Total Organic Carbon (TOC) analysis plays a critical role in ensuring water quality across pharmaceutical, environmental, and high purity industrial applications.

This webinar provides an overview of TOC fundamentals, the principles behind calibration, system suitability testing, and verification, and the regulatory framework that governs these practices.

Participants will gain practical insight into the carbon “family tree,” oxidation and detection mechanisms, along with TOC instrument performance requirements.

The session also addresses real world challenges - such as calibration drift, storage related standard degradation, and system suitability failures - and offers best practices for troubleshooting, maintenance, documentation, and long term performance trending.

Whether you are new to TOC or looking to deepen operational control, this webinar delivers the knowledge required to sustain a robust, compliant, and defensible TOC testing program.

What you will learn:

• Core principles of TOC measurement, and carbon fraction fundamentals.
• How calibration, system suitability, and verification ensure accurate, compliant TOC results.
• Practical strategies for troubleshooting TOC issues and maintaining long term instrument performance.

Who should attend:

This webinar is designed for Quality Assurance (QA) and Quality Control (QC) managers, Analytical chemists and laboratory scientists, Laboratory managers and supervisors, Method development and validation scientists, Pharmaceutical and biopharmaceutical manufacturing personnel.

Speaker: Christy Abbas, PhD (Sr. Product Marketing Manager, Waters ERA)

Christy has been with Waters ERA for six and a half years. Her career spans roles at an instrument manufacturer, a biopharmaceutical laboratory, and a mining company. She earned her PhD in Applied Chemistry from the Colorado School of Mines.

Throughout her career, Christy has supported the nuclear, pharmaceutical, and chemical industries, as well as academia. Drawing on her background in analytical chemistry, product development, marketing, and sales, she is focused on expanding Waters ERA’s product portfolio to better meet evolving customer needs.