Thermo Scientific picoSpin Series II NMR Spectrometers

Význam tématu

The accessibility of NMR spectroscopy at benchtop level bridges the gap between high-field instruments and on-site analysis, enabling rapid structural verification, reaction monitoring, and routine quality control without the need for cryogens or extensive lab infrastructure.

Cíle a přehled studie / článku

This overview presents the design, performance characteristics, and practical applications of the Thermo Scientific picoSpin Series II NMR spectrometers, highlighting two models optimized for sensitivity and bench space constraints.

Použitá metodika a instrumentace

The picoSpin Series II instruments incorporate:

• Permanent rare earth magnet: 2 Tesla (82±1 MHz) or 1.1 Tesla (45±1 MHz)
• Temperature stabilization of the magnetic field
• Capillary cartridge assembly: PTFE/quartz/316 stainless steel, 400 µm ID, 40 µL sample volume
• Sample introduction via syringe with Luer-lok needle or needleless adapter
• Ethernet connectivity and embedded web server for data acquisition
• Web-based user interface and Mestrelab Mnova™ software (one-year license)

Hlavní výsledky a diskuse

The key performance metrics and operational advantages include:

• Chemical shift resolution better than 20 ppb at 80 MHz and 40 ppb at 45 MHz
• High spectral resolution comparable to lower-field high-end systems without cryogenic requirements
• Reduced sample volume and solvent consumption (40 µL), enhancing cost efficiency
• Compact footprints: picoSpin 45 (17.8 × 14.6 × 29.2 cm, 5 kg) and picoSpin 80 (43.2 × 35.6 × 25.4 cm, 19 kg)
• Fast hardware enabling up to fourfold increase in throughput

The discussion emphasizes reliable operation in standard laboratory environments, minimal maintenance, and the balance between resolution, sensitivity, and portability.

Přínosy a praktické využití metody

Benchtop NMR spectroscopy with the picoSpin Series II offers:

• Real-time reaction monitoring in synthetic and process chemistry
• Routine QA/QC in pharmaceutical and chemical manufacturing
• Educational applications with intuitive software for training students
• Reduced operational costs by eliminating cryogens and large solvent volumes

Budoucí trendy a možnosti využití

Emerging developments may include:

• In-line integration with flow reactors and automated synthesis platforms
• AI-driven spectral interpretation and predictive analytics
• Further miniaturization and increased field strength in portable formats
• Cloud-based data management and remote access for distributed laboratories

Závěr

The Thermo Scientific picoSpin Series II benchtop NMR systems democratize high-resolution NMR analysis by combining robust permanent magnets with user-friendly interfaces and low operational costs, supporting a wide range of academic, industrial, and educational applications.

Reference

Thermo Fisher Scientific. picoSpin Series II NMR Spectrometers Product Specifications. 2016.