CRM Ca, K, Mg, Na, P, S - Aqueous calibration solution ASTASOL® AN9097MN

Importance of the Topic

Aqueous calibration solutions with certified concentrations of major elements are essential for ensuring accuracy and traceability in quantitative analytical methods. Reliable reference materials support quality assurance in laboratories, regulatory compliance and inter-laboratory comparability.

Objectives and Study Overview

The primary objective was to develop and certify a multi-element aqueous calibration solution (ASTASOL AN9097MN) containing Ca, K, Mg, Na, P and S at defined concentration levels. The study covers formulation, homogeneity, stability assessment and traceability to SI units and primary standards.

Methodology and Instrumentation

The solution was prepared gravimetrically using high-purity reagents and ultrapure water. Certified values and uncertainties were established at 20 °C.

Instrumental and primary methods used for characterization

• Gravimetric and titrimetric assays (complexometric titration with EDTA for Ca and Mg; gravimetric for P and S)
• Atomic spectrometry techniques (AAS, AES, ICP-OES, ICP-MS) calibrated against independent CRMs (e.g. NIST SRM)

Main Results and Discussion

The solution density is 1.0053 ± 0.0005 g/cm3. Certified concentrations of each analyte are 100.0 ± 0.2 mg/L (equivalent to 99.5 ± 0.3 mg/kg). Homogeneity and stability tests confirmed uniform composition and shelf life of three years unopened, with 12 months usability after first opening. Trace impurity levels were determined by AAS, ICP-OES and ICP-MS and remain below method detection limits, provided for information purposes only.

Benefits and Practical Applications

• Enables precise calibration and validation of quantitative methods in atomic and molecular spectrometry and selected electroanalytical techniques
• Supports method development, routine analysis and quality control in environmental, food, pharmaceutical and industrial laboratories
• Provides direct traceability to SI units and recognized primary standards

Future Trends and Potential Applications

Advancements may include expansion to additional elements, lower concentration levels for ultra-trace analysis and multi-matrix calibration kits. Integration with digital certificates and blockchain for real-time traceability is a potential development.

Conclusion

ASTASOL AN9097MN delivers a robust, SI-traceable calibration solution for major inorganic analytes, fulfilling stringent requirements for homogeneity, stability and uncertainty. It enhances reliability and comparability of quantitative analyses across diverse fields.

Reference

Gravimetric and titrimetric characterization methods traceable to NIST SRM 928, 3109a, 3131a, 3152a, 3154 and in-house standards; atomic spectrometry techniques calibrated with independent reference materials.