Metrohm NanoRam Product Line

Importance of the topic

Handheld Raman spectroscopy has become a critical tool for rapid raw material identification and verification in pharmaceutical and chemical industries. It enables non-destructive, on-site analysis without extensive sample preparation, ensuring supply chain integrity, regulatory compliance and operational efficiency.

Objectives and overview

This document presents the NanoRam product line, including method development, library building and user training services. It outlines the technical specifications of two handheld Raman models (785 nm and 1064 nm excitation), standard and optional accessories, performance validation and compliance features.

Methodology and instrumentation

The NanoRam and NanoRam-1064 systems employ diode lasers at 785 nm (up to 300 mW) or 1064 nm (up to 420 mW) with adjustable power settings. Spectral ranges cover 176–2900 cm⁻¹ (~9 cm⁻¹ resolution) for the 785 nm unit and 176–2500 cm⁻¹ (~11 cm⁻¹ resolution) for the 1064 nm unit. Detection is achieved via TE-cooled linear CCD arrays (785 nm) or InGaAs arrays (1064 nm). Standard accessories include point-and-shoot adapters, liquid vial holders, immersion probes, bottle and polystyrene validation attachments. Optional items extend functionality with tablet holders, right-angle and large spot adapters.

Main results and discussion

Both devices deliver fast identification through two operation modes: Investigation Mode using Hit Quality Index (Match/No Match) and Identification Mode based on statistical p-values (Pass/Fail); mixture analysis is also supported. Built-in USP libraries facilitate immediate raw material checks. The systems comply with 21 CFR Part 11 and carry IP64/IP65 ratings, ensuring suitability for regulated environments. Battery operation exceeds four hours, with options for rechargeable Li-ion or CR123 batteries.

Benefits and practical applications

• Immediate, in-field verification of incoming materials and finished products
• Minimized risk of mislabeling and cross-contamination
• Reduced downtime by avoiding lab-based analyses
• Enhanced regulatory compliance through audit-ready electronic records

Future trends and opportunities

Advances in miniature optics and chemometric algorithms will further improve sensitivity and spectral range. Integration with cloud-based libraries and AI-driven spectral matching can enable real-time remote support. Expanding capabilities for polymer and low-concentration mixtures will broaden application domains.

Conclusion

The NanoRam handheld Raman instruments provide versatile, reliable solutions for rapid raw material identification. Their robust design, comprehensive software and compliance features make them indispensable tools for quality assurance, process monitoring and regulatory adherence in modern analytical laboratories.

References

• Doc-Rev 400000375-A (02/04/2021) NanoRam Product Line Data Sheet