Metrohm i-Raman Prim portable Raman spectrometer

Significance of the topic

Raman spectroscopy has become a cornerstone technique in analytical chemistry due to its non-destructive nature, molecular specificity and capability to operate in situ. Portable, high-sensitivity systems expand these advantages into diverse environments such as field studies, process monitoring and regulated pharmaceutical settings. The combination of low noise detection, high throughput optics and flexible sampling makes real-time qualitative and quantitative analysis of complex materials achievable outside traditional laboratory confines.

Goals and overview of the article

This document introduces the i-Raman Prime, a fully integrated portable Raman spectrometer optimized for high sensitivity, wide spectral coverage and user-friendly operation. The aim is to present its performance highlights, application scope and software ecosystem supporting diverse analytical workflows, from bioscience to materials research.

Methodology and instrumentation

The i-Raman Prime system integrates several key components:

• Excitation lasers: 532 nm (35–42 mW) and selectable 785 nm/1064 nm (340–455 mW) outputs with adjustable power control.
• Sampling probe: Fiber-optic probe compatible with external trigger, video microscope adapter for visual alignment and interchangeable stand-off lenses up to 6 m working distance.
• Detector: High-quantum-efficiency CCD for visible/NIR range and InGaAs array for 1064 nm excitation, both cooled to reduce noise.
• Spectrometer: High-throughput design delivering spectral resolution down to <6 cm⁻¹ and coverage from 100 to 3400 cm⁻¹.
• Embedded control: Touchscreen tablet running BWSpec® for acquisition and monitoring; optional BWID® and BWIQ® chemometric software for identification, FDA-compliant workflows, multivariate analysis and real-time predictions.

Main results and discussion

Performance evaluation shows excellent signal-to-noise ratio enabling detection of low-concentration analytes and subtle spectral differences. Integration times span milliseconds to minutes, supporting rapid screening and detailed quantitation. Compatibility with STRaman® technology extends capabilities for through-package and large-area measurements. The modular software suite streamlines tasks from routine material verification to advanced chemometric modeling.

Benefits and practical applications

Key advantages:

• Mobility: Battery operation and lightweight design facilitate field deployment.
• Speed: High throughput optics reduce measurement times, critical for process analytical technology (PAT).
• Versatility: Broad spectral range and flexible sampling support bioscience, pharmaceuticals, forensics, geology and materials science.
• User-friendly: Touchscreen interface and comprehensive software lower the barrier to advanced Raman analysis.

Future trends and possibilities of use

Emerging areas include integration with automated sampling platforms and IoT networks for continuous process monitoring, expansion of STRaman® capabilities for quality assurance in packaging, and enhanced AI-driven spectral interpretation. Advances in detector technology may further improve sensitivity and extend measurements into challenging matrices.

Conclusion

The i-Raman Prime system delivers research-grade Raman performance in a portable form factor, combining high sensitivity, flexible sampling and robust software. It addresses the growing demand for in-field and real-time analysis across multiple industries, offering a powerful tool for both qualitative identification and quantitative monitoring.

Reference

B&W Tek. i-Raman Prime System Datasheet, Doc-Rev: 280001287-D (2020).