Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 25th May 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, Shimadzu &nbsp;and Thermo Fisher Scientific!<h3>1. Agilent Technologies: Analysis of Soil and Sediments by ICP-MS with Advanced Sample Introduction Tools</h3>Simplified sample preparation enabled by the Agilent Mira Mist Nebulizer and an In-Line Particle Filter<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_enviro_soil_sample_prep_9500_icp_qqq_5994_9126en_agilent_8299f007e9.pdf">Full PDF for download</a></li></ul>ICP-MS is widely employed for monitoring inorganic elements in soil and sediments, with established methods such as US EPA 6020B providing a validated framework for the accurate, multi‑element analysis of environmental samples.1 In a separate study, we demonstrated the outstanding performance capabilities of the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> (ICP-QQQ) in compliance with EPA 6020B requirements.2 The instrument, which includes the Ultra High Matrix Introduction (UHMI) system for enhanced plasma stability and robustness, employed Advanced Helium Mode (AHM) and Air cell mode to achieve lower limits of detection (LODs) compared to conventional cell gas approaches.3,4The two collision/reaction cell (CRC) modes of operation were enabled by the Agilent Dual-Cell System (DCS) —a unique CRC that provides the following performance advantages when operated in AHM and Air cell mode: – AHM – This innovative He-based gas collision-cell mode significantly enhances sensitivity for low-mass analytes while providing robust interference removal across the entire mass range. – This single gas mode eliminates the need for multiple modes, replacing no gas, conventional He, and high energy (HE) He mode. – Air cell mode – Using oxygen (O2 ) from air and an integrated air filter for the 9500 ICP-QQQ, Air cell mode leverages reactions between O2 and analytes to improve detection limits (DLs) for oxygen-reactive species. – Air cell mode effectively eliminates interferences, including M++ that are challenging to resolve using He-based gas methods.5 – With an unlimited supply of O2 in air, Air cell mode eliminates the need for O2 gas cylinders, reducing operating costs and simplifying workflows.Of all the ICP-MS nebulizers, the Agilent Mira Mist nebulizer offers the best resistance to concentrated acids and organic solvents. Its parallel path design ensures good tolerance to high levels of particulates and total dissolved solids (TDS), providing excellent resistance to clogging. In this study, the 9500 ICP-QQQ equipped with an in-line particle filter and Mira Mist nebulizer was used to determine trace and major elements in five environmental certified reference materials (CRMs) and a real sediment sample. The performance of the method was evaluated according to criteria set out in EPA Method 6020B.<h4>Experimental&nbsp;</h4><h5>Instrumentation&nbsp;</h5>All measurements were performed using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a> that includes the following standard components: nickel (Ni) interface cones and newly designed DCS cell. The design features and functionality of the 9500 and DCS are explained elsewhere.3,4 The 9500 was also equipped with the optional Agilent Advanced Valve System (AVS&nbsp;MS) discrete sampling system for improved productivity. The AVS&nbsp;MS system’s high-speed piston pump works seamlessly with the Agilent SPS 4 and SPS&nbsp;6 autosamplers for sample delivery, ensuring the high sample throughput necessary to meet the operational needs of most environmental testing laboratories.To optimize signal stability with the Mira Mist nebulizer, the nebulizer pump speed was adjusted and a makeup gas was introduced (Table 1). In the 9500 ICP-QQQ, both the makeup gas and dilution gas can be added, enabling finer control of the plasma gas flow rates to optimize signal %RSD within the target sensitivity zone. The lens parameters were set automatically using the Autotune function in the software. The in-line filter’s internal volume is sufficiently small that its presence does not influence AVS MS sample introduction timing or method parameters. As a result, the same settings were used with and without the filter installed (Table 2).<h4>Conclusion&nbsp;</h4>In this study, sediment samples were analyzed in accordance with EPA Method 6020B using the Agilent 9500 ICP‑QQQ with UHMI and the optional AVS MS. The system was equipped with advanced sample introduction components, including the Mira Mist nebulizer and an in‑line particle filter.&nbsp;The combination of the Mira Mist nebulizer and in-line filter enabled the analysis of sediment digests without a dedicated filtration step, reducing sample preparation time and consumable costs. At the same time, the configuration minimized the risk of sample introduction blockages, supporting robust and reliable long-term ICP-QQQ operation for complex environmental matrices.Overall, the 9500 ICP-QQQ with the Mira Mist nebulizer and the in-line particle filter achieved excellent analytical data:&nbsp;<ul><li>Low detection limits in the low ng/L (ppt) range for most analytes&nbsp;</li><li>The same or similar washout efficiency of sticky elements as a standard sample introduction configuration&nbsp;</li><li>The same sample introduction timing, regardless of whether the filter was installed or not&nbsp;</li><li>Method robustness and reproducibility over more than eight hours of continuous measurements, as demonstrated by the recoveries of ISTDs and CCVs within the limits specified in EPA Method 6020B&nbsp;</li><li>Recoveries of all certified elements in the five environmental CRMs, matrix spike sample, and spiked real sediment sample within ±10%, confirming the effective control of interferences using AHM and Air cell mode&nbsp;</li></ul>The study has highlighted how the 9500 ICP-QQQ with the Mira Mist nebulizer and in‑line particle filter enhances sample preparation efficiency and analytical performance for the analysis of complex sediment digests.<h3>2. Shimadzu: Analysis of Inorganic Elements in Urine Using EDXRF</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01007_en_c3bd71bbb3.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>Inorganic elements in urine can be quantified at the ppm level without any complicated sample pretreatment.</li><li>Qual-quantitative analysis is possible using the FP (Fundamental Parameter) method, which does not require standards.</li><li>Qual-quantitative results are obtained within 10 minutes per sample.</li></ul>Inorganic element poisoning, including heavy metals, is caused by accidents or criminal incidents, and the causative elements are diverse. Although some of these elements are highly toxic, there are cases in which it is difficult to distinguish them at an early stage because they lack specific symptoms of poisoning. Therefore, analytical methods for rapid screening of these elements are required in forensic research.&nbsp;Inorganic elements are generally analyzed by ICP-AES or ICP-MS. Although these techniques allow trace-level quantitation, they require chemical pretreatment such as dilution and deproteinization, and the samples are limited to liquid specimens. In contrast, energy dispersive X-ray fluorescence spectrometer (EDXRF - <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=EDX-7200">EDX-7200</a>) offers sufficient sensitivity in the concentration range associated with poisoning and enables simple, non-destructive analysis in a short time.&nbsp;This application describesthe results of quantitative analysis of 15 elements in urine by the calibration curve method, and qualquantitative analysis by the FP (Fundamental Parameter) method based on sensitivity coefficients installed in the instrument. The errors in the quantitative values obtained by the FP-based qualquantitative analysis method were approximately ±20 %, indicating that sufficient quantitative accuracy was achieved. Screening can be performed within 10 minutes persample.<h4>Conclusion</h4>The FP method demonstrated high accuracy for quantitation without calibration curves. Furthermore, urine samples do not require complicated pretreatment such as protein removal, and the analysis time is as short as approximately 10 minutes per sample. This method is well suited for poisoning screening in forensic research.<h3>3. Thermo Fisher Scientific: Analysis of copper alloys with the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1978">ARL X900 XRF Spectrometer</a></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/analysis_of_copper_alloys_arl_9900_an41427_203b52e126.pdf">Full PDF for download</a></li></ul><h4>Copper alloys&nbsp;</h4>are very important products because they are used for many applications and many manufacturing processes as described in the next few paragraphs. It is important to accurately analyze these materials to confirm compliance of their chemical specifications that imply physical properties, like conductivity, compressive strength, hardness, resistance to traction and to abrasion. High product quality and efficient production can be ensured with accurate analysis results. Copper alloys Pure copper is mixed with other elements to produce a wide range of alloys: Brasses (Cu-Zn), bronzes (Cu-Sn), gun metal (Cu-Sn-Zn) used for casting due to its excellent fluidity, for valves, taps and water fittings. Manganese bronzes (Cu-Zn-Mn) are not true bronzes as Sn is not the essential constituent. Used for rudders, propellers, and ship fittings. Cupro-nickel (Cu-Ni) used for coins, tubes, wires, electrical resistances, and thermocouples. Nickel silver (Cu-Ni-Zn) used for marine applications, car radiators and fittings.&nbsp;<h4>Brass&nbsp;</h4>One of the most important non-ferrous engineering alloys. It covers a large range of physical properties with multiple applications. Copper can hold about 39% of zinc in solid solution. Alloys containing less than 39% Zn are known as α-brasses. This brass (70/30) is very widely employed for cartridge, cases, condenser tubes, etc. From 39% to 46% of Zn, a β-solid solution gives αβ-brass. This alloy (60/40) is found in extensive engineering applications with enhanced corrosion resistance used in marine applications. Alloys containing more than 49% Zn are very hard and only used for brazing brasses.<h4>Instrument parameters and conditions&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1978">ARL X900 XRF Spectrometer</a> can accommodate up to 24 fixed monochromator channels alongside the goniometer or up to 32 fixed monochromator channels when no goniometer is fitted. New high counting fixed channel monochromators using an SCX detector are available to further improve the precision of analysis, especially for elements like Cu, Zn and Ni.Our unique proprietary Moiré fringe goniometer ensures speed, flexibility and reliability of analysis thanks to the clever frictionfree positioning system. Up to nine crystals and four collimators can be fitted. With the two detectors (flow proportional and scintillation counters), precise elemental analysis from Boron to Californium is possible.&nbsp;The ARL X900 XRF spectrometer can be calibrated using commercially available certified reference materials (CRM) or well analyzed samples from the user. Calibrations can be delivered from the factory, hence reducing the commissioning time at the customer’s site.&nbsp;It should be stressed that an XRF spectrometer is a very accurate comparator, but the accuracy of the final analysis is entirely dependent on the quality of the standards used for calibration and on the care and reproducibility of sample preparation which must be identical for CRMs and for routine samples as well.This application note only includes data obtained mostly on fixed channels and on some goniometer channels. For more results using goniometer channels please refer to AN41426.<h4>Conclusion&nbsp;</h4>Analysis of all sorts of copper alloys can be performed with ease using the ARL X900 Simultaneous-Sequential XRF Spectrometer. The performance of the Moiré fringe goniometer is such that it can be used for analysis of any elements that are not fitted as fixed channels. The analysis on the goniometer is done while the fixed channels are measuring. In addition, it can be used as a backup in case of failure of any of the fixed channels.&nbsp;Appropriate calibrations for copper alloys can be delivered turnkey from the Thermo Fisher Scientific factory. In this case the commissioning time of the spectrometer is reduced to a minimum.&nbsp;The precision is excellent in these matrix types for routine or R&amp;D analysis, especially when the new high counting fixed channel monochromator is used for elements like Cu, Zn, and Ni.&nbsp;Furthermore, operation is made easy through the innovative <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2029">Thermo Scientific™ OXSAS™ Software</a> that operates with the latest Microsoft Windows® package.&nbsp;Thermo Fisher Scientific’s long experience in metals analysis comes from an installed base of over 2,000 XRF spectrometers worldwide. The ARL X900 spectrometer is the answer to your metallurgical analysis needs, whether they involve incoming material control, metal QC, or production analysis. Working 24 hours a day and 7 days a week, the ARL X900 spectrometer delivers dependable performance year after year. The high performance of the ARL X900 XRF Spectrometer will meet your analytical needs today and in the future

News from LabRulezICPMS Library - Week 22, 2026

In various debates,&nbsp;Aristotle, Leonardo da Vinci, and Leibniz are often described as the last men who mastered all the knowledge of their time. Today, however, we are confronted with such an overwhelming amount of information that it is no longer within the power of a single person to&nbsp;comprehend&nbsp;it all. As society develops, we naturally lose comprehensive&nbsp;expertise&nbsp;within individual disciplines.There is simply too much information for everyone to know everything. Likewise, we have inevitably reached a point where it is impossible for every scientist to&nbsp;fully&nbsp;understand and master all scientific approaches and methods used&nbsp;in a given&nbsp;field. And this is precisely where some of the errors in scientific literature originate.<h4>X-ray&nbsp;Photoelectron&nbsp;Spectroscopy (XPS) as a Case Study</h4>To illustrate this phenomenon, let us focus on a method commonly used in materials science: X-ray Photoelectron Spectroscopy (XPS). XPS is a technique that provides information about the chemical composition of samples, including the chemical states in which individual atoms are found. Simply put, it tells us which elements are present in a sample and how they are chemically bonded to one another.The method is based on the internal photoelectric effect, in which electrons are emitted from atoms&nbsp;as a result of&nbsp;absorbing X-ray photons. From the measured kinetic energy of the emitted electrons and the known energy of the photons, we can&nbsp;determine&nbsp;the binding energy of the electrons in the atoms. This binding energy is characteristic of each element and shifts slightly depending on how the atom is bonded to its surroundings. In the measured spectrum, each chemical state corresponds to a peak at a specific energy. For example, if we analyse PET polymer chains using XPS, we discover not only that carbon and oxygen are present in the sample, but also that there are two types of oxygen atoms in a 1:1 ratio and three types of carbon atoms in a 1:1:3 ratio. Based on known information about the energies of individual bonds, we then assign the observed peaks to the bonds present in PET.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Jakub_Rozboud_Vice_dat_mene_pochopeni_pripadova_studie_XPS_2_37d42e7fa2.jpeg" alt="CEITEC/Jan Čechal: More Data, Less Understanding: An XPS Case Study: X-Ray Photoelectron Spectroscopy (XPS) at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Jakub_Rozboud_Vice_dat_mene_pochopeni_pripadova_studie_XPS_2_37d42e7fa2.jpeg 208w," sizes="100vw" width="1600" height="1200"><h4>The Majority of Spectra Is Misinterpreted</h4>XPS is a widely used method that, especially when combined with other surface analysis techniques, provides highly valuable data about sample composition. Today, XPS spectrometers are standard equipment wherever materials research is conducted. After brief training, most users&nbsp;can&nbsp;operate&nbsp;the spectrometers and&nbsp;measure&nbsp;their own spectra. So,&nbsp;where is the problem?In 2020, a&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://pubs.aip.org/avs/jva/article/38/6/061204/1023649/Assessment-of-the-frequency-and-nature-of">study</a>&nbsp;was published showing that approximately 60% of XPS spectra in scientific journals were interpreted incorrectly, or at least, questionably. The conclusions were based on the examination and evaluation of XPS analyses published over a six-month period in 2019 across three different journals. The first had a narrow disciplinary focus (IF 25), the second focused on&nbsp;materials&nbsp;surface analysis, and the third was a general scientific journal&nbsp;containing&nbsp;a large number of&nbsp;publications in materials science. The results were alarming: on average, 60% of the spectra had been interpreted incorrectly.<h4>Modeling the Spectra, i.e. Fitting, Increased the Error Rate</h4>When only the measured spectra were published and conclusions were drawn directly from them, the situation was&nbsp;not quite so&nbsp;severe. However, this changed dramatically once spectral&nbsp;modelling&nbsp;(so-called fitting) was used. Through fitting, we&nbsp;attempt&nbsp;to obtain more detailed information when spectral peaks have complex shapes caused by the presence of multiple chemical states for each element. Here, the error rate reached 80%.&nbsp;Roughly 40%&nbsp;of these were&nbsp;very serious&nbsp;errors that&nbsp;essentially invalidated&nbsp;the conclusions of the published XPS analyses. And we are talking about respectable scientific journals. Sixty percent incorrectly interpreted XPS measurements is not a negligible problem.In response to this study, my colleagues and I prepared&nbsp;a&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://pubs.aip.org/avs/jva/article/41/3/038501/2888098/Perspective-on-improving-the-quality-of-surface">publication</a>&nbsp;examining the future of science&nbsp;in light of&nbsp;these findings, the causes of the current situation, and&nbsp;possible ways&nbsp;to remedy it.&nbsp;A deeper examination of incorrectly interpreted spectra quite clearly shows that most of the mistakes could have been easily avoided.&nbsp;In essence, only&nbsp;a basic understanding of&nbsp;XPS’s fundamental principles&nbsp;was missing. Spectral modelling reflects the process of photoemission&nbsp;and thus&nbsp;must follow its physical principles. Many spectral interpretations contradict quantum mechanics (and some authors even acknowledge this themselves in their papers), while others are simply inconsistent. In many cases, the process resembles drawing curves&nbsp;like&nbsp;those seen in the literature,&nbsp;rather than a well-founded interpretation of measured data.&nbsp;<h4>The Invention of New Errors</h4>So&nbsp;is the problem simply that mistakes spread from one publication to another? Initially, we thought so. However, a&nbsp;subsequent&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://pubs.aip.org/avs/jva/article/42/6/063213/3322271/Following-the-propagation-of-erroneous-x-ray?guestAccessKey=">study</a>&nbsp;showed otherwise. In incorrectly interpreted analyses that cited&nbsp;a single&nbsp;prominent example, the&nbsp;problem&nbsp;was usually not the&nbsp;reproduction&nbsp;of specific mistakes, but the invention of entirely new ones.&nbsp;Essentially, the&nbsp;goal was merely to include a citation from a high-impact&nbsp;journal that appeared to support the claims made in the article. Authors were therefore not copying&nbsp;particular errors, but citing superficially similar work,&nbsp;without understanding the context.Is this a manifestation of the often-discussed crisis of science? Not yet. We are still in a&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://pubs.aip.org/avs/jva/article/41/3/038501/2888098/Perspective-on-improving-the-quality-of-surface">pre-crisis stage</a>. We could speak of a true crisis, were&nbsp;the entire body of scientific literature&nbsp;to&nbsp;become worthless because we were&nbsp;no longer able to&nbsp;determine&nbsp;what is true and what is not. We are not there yet. However, the results of the&nbsp;above-mentioned&nbsp;studies&nbsp;1suggest that we are heading in that direction.Everything begins with scientists themselves. To avoid such a crisis, efforts must be made on many fronts. In the past, XPS analysis was the domain of specialists. Today, however, it is used by scientists and students from many&nbsp;different backgrounds, who are often trained only to&nbsp;operate&nbsp;the spectrometer, not to interpret the measured data. For them, it is just one of many methods used to assemble the mosaic of a new publication. But do they have enough time to deeply understand every method they use, when they are expected to publish,&nbsp;and&nbsp;above all, to&nbsp;publish quickly?<h4>Am I Sure that what I write Is True?</h4>We must pay close attention to education: scientists need to be taught how to&nbsp;properly work with XPS data. To this end, we have written a&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S266652392300168X?via%3Dihub">summary</a>&nbsp;of the most common mistakes and how to avoid them. But papers alone are not enough. Last year,&nbsp;therefore,&nbsp;I began offering a two-day course at CEITEC BUT, in which I primarily teach the physics and chemistry underlying the method, followed only afterward by mathematical&nbsp;modelling, while also highlighting the most common sources of error. Since we live in a fast-paced world, I also prepared a short&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://arxiv.org/abs/2512.24756">text</a>&nbsp;summarizing the basics of XPS in 20 minutes. Because even 20 minutes can prevent most of the fundamental mistakes in spectral interpretation.Unfortunately, this is not just an XPS story. Similar situations may exist in other analytical methods and in other scientific disciplines as well.&nbsp;So&nbsp;what can we do about it? I believe the most&nbsp;important step&nbsp;is a change in mindset. Every (co-)author should honestly ask themselves before&nbsp;submitting&nbsp;a publication&nbsp;–&nbsp;and answer honestly: “Am I sure that what we are writing is true?”<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Jakub_Rozboud_Vice_dat_mene_pochopeni_pripadova_studie_XPS_ecd45c1452.jpg" alt="CEITEC/Jakub Rozboud: More Data, Less Understanding: An XPS Case Study: Jan Čechal, CEITEC Brno University of Technology. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Jakub_Rozboud_Vice_dat_mene_pochopeni_pripadova_studie_XPS_ecd45c1452.jpg 235w," sizes="100vw" width="1600" height="1067">

More Data, Less Understanding: An XPS Case Study 

<div><div>Dr. Tomáš Cihlář, Senior Vice President of Research, Virology at Gilead Sciences, and Dr. Jeffrey Birnbaum, an American pediatrician who has long worked with young Americans at risk of HIV infection or living with the virus, visited IOCB Prague for a joint lecture. The event focused on the future of long-acting HIV prevention and treatment.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_f5ca13985a.jpg" alt="IOCB Prague/Tomáš Belloň: From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague: Dr. Tomáš Cihlář, Gilead Sciences" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_f5ca13985a.jpg 234w," sizes="100vw" width="2000" height="1333"></div></div><div>Modern HIV treatment is shifting from daily medication to long-acting prevention. This was the central theme of the joint lecture titled <a target="_blank" rel="noopener noreferrer" href="https://www.uochb.cz/en/event-calendar/372/joint-lecture-tomas-cihlar-jeffrey-birnbaum">HIV Treatment – From Bench to Clinical Practice</a>. “HIV is by no means just a medical problem, but also a social, economic, psychological, and legal one,” said Institute Director Prof. Jan Konvalinka in his opening remarks.In 2022, Gilead Sciences’ drug lenacapavir was launched on the U.S. market. The company has a long-standing collaboration with OICB Prague, for example on tenofovir – a substance that became the basis for modern HIV drugs.“During the development of lenacapavir, we broke all the rules we’re supposed to follow when searching for new drugs,” said Dr. Tomáš Cihlář in his lecture, describing the creation of the drug that targets the virus’s protein envelope. Today, it is used not only for treatment but also for preventing infection. Its development took several decades. “Around 2010, we even wanted to give up, but then a new candidate molecule emerged,” concluded Tomáš Cihlář, recounting the story of the drug’s development.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_2_4e1804920e.jpg" alt="IOCB Prague/Tomáš Belloň: From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague: Jeffrey Birnbaum, M.D., MPH, SUNY Downstate Health Sciences University, NY, USA" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_2_4e1804920e.jpg 234w," sizes="100vw" width="2000" height="1333">The FDA and the European Commission approved the preventive use of lenacapavir in 2025, but research continues. The ongoing international clinical trial PURPOSE 365 is investigating whether the drug can be administered just once a year instead of the currently approved two injections.Dr. Jeffrey Birnbaum shared his experiences from daily hospital practice at SUNY Downstate Health Sciences University in Brooklyn. In his practice, he primarily sees young people from the transgender community, for whom a long-acting preventive injection is a particularly attractive option. “Patients don’t have to worry that someone will discover their medication. There’s also no risk of forgetting to take it, and they avoid pill fatigue, the long-term psychological exhaustion associated with the need to take medication regularly.”Although lenacapavir represents a significant medical advance, the way the drug reaches people is also crucial. Approximately 400 million people are currently at risk of HIV infection, particularly in sub-Saharan Africa. Although Gilead Sciences has six manufacturing partners on the African continent, current U.S. government cuts to HIV prevention funding are dramatically affecting the availability of HIV prevention programs.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_3_e7f4f6a043.jpg" alt="IOCB Prague/Tomáš Belloň: From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Od_kazdodennich_pilulek_k_jedne_injekci_rocne_UOCHB_navstivili_prukopnici_prevence_HIV_3_e7f4f6a043.jpg 234w," sizes="100vw" width="2000" height="1335"></div>

From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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From daily pills to one injection a year. HIV prevention pioneers visit IOCB Prague

More Data, Less Understanding: An XPS Case Study

News from LabRulezICPMS Library - Week 22, 2026