Bruker Online Neuroscience Summit 2026: Innovations in Brain Research
This summit will showcase groundbreaking research from leading researchers utilizing advanced imaging technologies, including Bruker two-photon microscopes, single-photon miniscopes and super resolution microscopes, to explore neuronal activity in the brain. Don't miss this chance to connect with the scientific community and stay at the forefront of neuroscience innovation.
Abstracts and Speaker Bios
Day 1 Presentations – May 5
Silent Synapses in Murine Hippocampal Cultures
- Brian D. Mueller, Ph.D. (Postdoctoral Researcher, Charité – Universitätsmedizin Berlin, University of Utah)
- Date: Tuesday, May 5
- Time: 9:05 AM - 9:50 AM
Abstract: In hippocampal neuron cultures, most synapses have extremely low release probability and are silent. Here we show that silent synapses have a morphologically complete active zone and contain docked synaptic vesicles by electron microscopy. Further, we demonstrate that silent synapses are fully functional but muted by the essential docking factor Munc13-1. Synapses are activated by the DAG analog phorbol ester -- without modifications to the nanoscale organization of the synapse. Thus, the inhibitory C1 domain of Munc13 is a simple tuning mechanism for the weight of individual synapses in a neural circuit.
Day 2 Presentations – May 6
How to Dissect Behavior-Time-Locked Single-Cell Neural Temporal Dynamics in Freely Moving Mice by Mini1P and Mini2P
- Hyung Jin Choi (Seoul National University)
- Date: Wednesday, May 6
- Time: 8:10 AM - 8:45 AM
Abstract: Understanding how individual neurons contribute to specific behaviors requires precise neural activity imaging aligned with well-designed behavioral paradigms. This talk presents a framework for investigating behavior-time-locked neuronal roles using single-cell-level neural activity imaging in freely moving mice. We emphasize the importance of designing behavioral tasks that directly test neuroscience hypotheses, ensuring precise temporal alignment between neural activity and behavioral events. Understanding how individual neurons contribute to specific behavioral processes, such as food discovery, approach, consumption, reward learning, and extinction memory, requires precise neural activity imaging aligned with well-structured behavioral paradigms. We emphasize the importance of designing behavioral tasks that capture key moments in reward-related behaviors, ensuring precise temporal alignment between neural activity and behavioral transitions. By integrating advanced single-cell-level neural activity imaging mini1P and mini2P techniques with hypothesis-driven behavioral paradigms, we aim to elucidate the neuronal mechanisms underlying reward processing and learning, providing new insights into neural circuit function.
Imaging Synaptic Structure in Neurological Tissue With Single Molecule Localization Microscopy
- Abraham Kohrman, Ph.D. (Applications Specialist for Biological Microscopy, Bruker FM)
- Date: Wednesday, May 6
- Time: 10:00 AM - 10:45 AM
Abstract: TBD
