Shimadzu iMScope with iMLayer Matrix sprayer (Refurbished)

The Shimadzu iMScope with iMLayer Matrix Sprayer is an integrated imaging mass spectrometry (IMS) platform that uniquely combines optical microscopy and MALDI mass spectrometry imaging in a single instrument, enabling precise molecular visualization directly correlated with tissue morphology.

The device has been used very sporadically and is in excellent condition!

Key features

• Fully integrated optical microscope and MALDI-MS imaging system
• High spatial resolution molecular imaging directly correlated with histological features
• iMLayer matrix sprayer for uniform, reproducible matrix deposition
• Seamless transition between optical observation and MS imaging
• Designed for biological, pharmaceutical, and clinical research

Mass spectrometry and imaging performance

• MALDI ion source optimized for imaging applications
• High mass accuracy and sensitivity suitable for lipids, metabolites, peptides, and drugs
• Flexible imaging resolution depending on application and sample type
• Reliable signal reproducibility across large tissue sections

Optical microscopy integration

• Built-in optical microscope for sample observation and region-of-interest (ROI) selection
• Direct overlay of optical and MS images without external alignment
• Supports histological workflows and correlative analysis

iMLayer matrix sprayer

• Automated matrix application system optimized for MALDI imaging
• Uniform matrix coating improves ionization efficiency and image quality
• Reproducible spraying conditions reduce operator-dependent variability
• Suitable for common MALDI matrices used in biological imaging

Software and data handling

• Integrated Shimadzu imaging and MS control software
• Tools for image reconstruction, molecular distribution mapping, and data comparison
• Supports correlation of MS data with optical images and histological stains

Typical applications

• Spatial metabolomics and lipidomics
• Drug distribution studies in tissues
• Biomarker discovery
• Pathology and translational research
• Pharmaceutical development and toxicology