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Ústav organické chemie a biochemie AV ČR
The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry.
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Scientists from IOCB Prague have improved materials for reconstructive and plastic surgery

Mo, 15.4.2024
| Original article from: IOCB Prague
Researchers from IOCB Prague and Ghent University have been working on improving the properties of gelatin-based materials, thereby expanding the possibilities of their use mainly in medicine.
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  • Photo: Tomáš Belloň / IOCB Prague: Scientists from IOCB Prague have improved materials for reconstructive and plastic surgery: Ondřej Groborz, PhD student from Tomáš Slanina Group at IOCB Prague.
  • Video: IOCB Prague: Scientists from IOCB Prague have improved materials for reconstructive and plastic surgery.

Researchers from IOCB Prague and Ghent University have been working on improving the properties of gelatin-based materials, thereby expanding the possibilities of their use mainly in medicine. In a paper published in ACS Applied Engineering Materials, they have presented 3D-printable materials that can be easily monitored using an X-ray machine or through computed tomography (CT).

Gelatin-based materials have been a hot topic of research in the last ten years because they are straightforward to produce, non-toxic, inexpensive, biodegradable and - most importantly - because they promote cell growth. For this reason, they are pre-eminently used in plastic and reconstructive surgery. After a surgeon places an implant made of such material into a wound, the body gradually breaks it down and replaces it with tissue of its own. These substances thus accelerate wound healing and even enable the remolding of tissues, for example when performing breast reconstruction after mastectomy. In addition, the materials can be used for 3D printing implants tailored to individual patients.

IOCB Prague: Ondřej Groborz, PhD student from Tomáš Slanina Group at IOCB Prague (Photo: Tomáš Belloň / IOCB Prague)

So far, however, there has been one big obstacle to tackle, namely that it has been very difficult to track the breakdown of these materials in the body using conventional imaging methods. And this very hurdle is one that researchers from IOCB Prague are working to overcome. A radiopaque (i.e. X-ray-contrast) agent newly added to the materials makes it possible to trace how quickly implants shrink over time and whether they are intact or damaged.

One person behind this research at IOCB Prague is Ondřej Groborz from the research team of Tomáš Slanina (Photoredox chemistry group). He explains: ‘A whole series of academic papers is being written on this topic. The first of them introduces a gelatin-based material that can be monitored using magnetic resonance imaging. In our second article, recently published in Applied Engineering Materials, we endow the materials with X-ray and CT detectability.

IOCB PRague: Scientists from IOCB Prague have improved materials for reconstructive and plastic surgery. (Left) Classical magnetic resonance imaging of a rat (¹H MRI), a transverse section at approximately the waist. The red arrow points to the implantation site of the new (fluorinated) implant; the white arrow points to the implantation site of the older type of implant. (Middle) Imaging of the same part of a rat but with the fluorine imaging method (¹⁹F MRI), the shape of the new implant is clearly visible in the image but the older type is not. (Right) Combining the ¹H MRI image and the ¹⁹F MRI image shows the size and shape of the implant and its anatomical location.

Because of this improvement, researchers can monitor these implants over time and observe their biodegradation and detect possible mechanical failures. These data are particularly useful in clinical practice. Based on the data obtained, the biodegradation of implants can be tailored to meet specific clinical requirements. This is because tissues in the human body grow at different rates, to which the properties of implants need to be adapted. The goal is to make these implants biodegrade at the same rate as healthy tissue grows.

Ondřej Groborz cooperates on this research with the Polymer Chemistry & Biomaterials Group (PBM) at Ghent University. Belgium is at the forefront in the medical use of implants with this structure. Moreover, the collaboration between IOCB Prague and Ghent University has potential to transcend into the commercial world. The two research institutions have already submitted a joint patent application concerning the use of the described materials in plastic and reconstructive surgery.

Resources

Groborz, O., Kolouchová, K., Parmentier, L., Szabó, A., Durme, B. V., Dunlop, D., Slanina, T., Vlierberghe, S. V. (in press). Photo-printable radiopaque hydrogels for regenerative medicine. ACS Applied Engineering Materials 2024. https://doi.org/10.1021/acsaenm.3c00533

Ústav organické chemie a biochemie AV ČR
 

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